P1.30 DIFFERENTIAL MEANING OF RETINAL ARTERIAL REMODELING AND AORTIC DISTENSIBILITY IN YOUNG HYPERTENSIVES

D. Rosenbaum; A. Redheuil; N. Kachenoura; P. Cluzel; A. Decesare; E. Koch; M. Paques; X. Girerd

doi:10.1016/j.artres.2013.10.059

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Volume 7, Issue 3-4, September 2013, Pages 118 - 118

P1.30 DIFFERENTIAL MEANING OF RETINAL ARTERIAL REMODELING AND AORTIC DISTENSIBILITY IN YOUNG HYPERTENSIVES

Authors

D. Rosenbaum¹^{, 2}, A. Redheuil², N. Kachenoura², P. Cluzel², A. Decesare², E. Koch³, M. Paques³, X. Girerd¹

¹Pitié salpêtrière Hospital, Cardiovascular Prevention Unit, Paris, France

²Laboratoire d’imagerie fonctionnelle, UPMC INSERM U 678, Paris, France

³Institut de la vision, CIC des XV/XX, Paris, France

Available Online 11 November 2013.

DOI: 10.1016/j.artres.2013.10.059 How to use a DOI?
Abstract: Objectives: Microvascular arterial remodelling has been linked with target organ damage and cardiovascular events. Our objective was to link retinal arterial remodelling assessed using a new interferometry technique (adaptative optics, AO) and ascending aortic function and geometry.

Methods: 9 patients (median age 43, range 30 to 58, 60% male) with primary hypertension underwent AO to measure retinal arteries wall to lumen ratio (WLR) index and a cardiovascular magnetic resonance exam (1.5T Siemens) of the proximal aorta. Ascending aortic diameters and strain were calculated using the ARTFUN software and an automated segmentation of SSFP cine acquisitions acquired in the axial view, during breath-holding, at the level of pulmonary bifurcation perpendicular to the aorta. Aortic strain was used to calculate aortic distensibility in each subject: distensibility (AD) =strain/cPP where cPP is the central pulse pressure obtained by tonometry (sphygmocor^®). Home Blood pressure (hBP) records were used to define BP levels

Results: Characteristics of the population are shown in table 1. In univariate analysis, retinal WLR was linked to systolic hBP (r= 0.53, p= 0,006) and weight (r= 0.38, p= 0,03) but not with any other risk factors. AD was linked to age (r= 0.53, p= 0,006), systolic hBP (r= 0.53, p= 0,006) and tobacco status. In multivariate analysis, the only significant determinants remaining were age for AD and systolic hBP for WLR.

Conclusion: In young hypertensives, AD and WLR are representative of 2 different arterial aging factors: age for AD and hypertension for WLR.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 7 - 3-4
Pages: 118 - 118
Publication Date: 2013/11/11
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2013.10.059 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - D. Rosenbaum
AU  - A. Redheuil
AU  - N. Kachenoura
AU  - P. Cluzel
AU  - A. Decesare
AU  - E. Koch
AU  - M. Paques
AU  - X. Girerd
PY  - 2013
DA  - 2013/11/11
TI  - P1.30 DIFFERENTIAL MEANING OF RETINAL ARTERIAL REMODELING AND AORTIC DISTENSIBILITY IN YOUNG HYPERTENSIVES
JO  - Artery Research
SP  - 118
EP  - 118
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.059
DO  - 10.1016/j.artres.2013.10.059
ID  - Rosenbaum2013
ER  -

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