Artery Research

<Previous Article In Issue
Next Article In Issue>
Volume 25, Issue Supplement 1, December 2019, Pages S173 - S173

P135 Assessment of Novel Blood Pressure Corrected Cardio-ankle Vascular Index in Response to Acute Blood Pressure Changes

Authors
Michal Mestanik1, Bart Spronck2, Alexander Jurko3, Andrea Mestanikova1, Tomas Jurko4, Mark Butlin5, Alberto Avolio5, Lucia Bona Olexova6, Zuzana Visnovcova1, Nikola Sekaninova6, Ingrid Tonhajzerova6, *
1Biomedical Center Martin and Department of Physiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia
2Department of Biomedical Engineering, Yale University, New Haven, Connecticut, USA; Department of Biomedical Engineering, CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, the Netherlands
3Pediatric Cardiology, external workplace of Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia
4Neonatologic Clinic, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, University Hospital Martin, Martin, Slovakia
5Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, Australia
6Department of Physiology and Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia
*Corresponding author. Email: ingridtonhajzerova@gmail.com
Corresponding Author
Ingrid Tonhajzerova
Available Online 17 February 2020.
DOI
10.2991/artres.k.191224.158How to use a DOI?
Abstract

Background: Cardio-ankle vascular index (CAVI) has long been considered a measure of arterial stiffness independent of short-term changes in blood pressure (BP) [1]. Recently and theoretically, CAVI was found to be partially affected by actual BP, thus, a novel BP-corrected index, CAVI0, was proposed to diminish these effects [2,3]. Direct, repeated measures experimental data comparing CAVI’s and CAVI0’s acute blood pressure dependence is lacking. Hence, the aim of this study was to assess the effects of short-term changes of BP on CAVI0 in comparison with standard CAVI.

Methods: 60 healthy adults were examined using vascular screening system VaSera 1500 N (Fukuda Denshi Co., Tokyo, Japan) during four examination periods lasting 5 minutes – baseline, cold pressor test (CPT), recovery period, and isometric handgrip exercise (IHE). CAVI and cardiovascular parameters for calculation of CAVI0 were measured after baseline, at the peak of pressor response to CPT, after recovery period, and at the peak of pressor response to IHE. CAVI, CAVI0, and mean BP were assessed for all periods.

Results: CAVI significantly increased during CPT compared to baseline rest (p = 0.008), returned to baseline values during recovery period (p = 0.011 compared to CPT), and significantly increased during IHE compared to recovery period (p = 0.002). No significant changes of CAVI0 were found. CAVI significantly correlated with changes in mean BP (p = 0.012; multilevel regression); CAVI0 did not (p = 0.570).

Conclusion: In this repeated measures, experimental, acute study, CAVI showed short-term blood pressure dependence, whereas CAVI0 did not.

Copyright
© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Download article (PDF)
View full text (HTML)

<Previous Article In Issue
Next Article In Issue>
Journal
Artery Research
Volume-Issue
25 - Supplement 1
Pages
S173 - S173
Publication Date
2020/02/17
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.2991/artres.k.191224.158How to use a DOI?
Copyright
© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - JOUR
AU  - Michal Mestanik
AU  - Bart Spronck
AU  - Alexander Jurko
AU  - Andrea Mestanikova
AU  - Tomas Jurko
AU  - Mark Butlin
AU  - Alberto Avolio
AU  - Lucia Bona Olexova
AU  - Zuzana Visnovcova
AU  - Nikola Sekaninova
AU  - Ingrid Tonhajzerova
PY  - 2020
DA  - 2020/02/17
TI  - P135 Assessment of Novel Blood Pressure Corrected Cardio-ankle Vascular Index in Response to Acute Blood Pressure Changes
JO  - Artery Research
SP  - S173
EP  - S173
VL  - 25
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.191224.158
DO  - 10.2991/artres.k.191224.158
ID  - Mestanik2020
ER  -