Artery Research

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Volume 25, Issue Supplement 1, December 2019, Pages S174 - S174

P136 Determinants of Arterial Stiffness in Children Using Population-indexed Anthropometric and Hemodynamic Parameters

Authors
Tommy Cai1, 2, Alice Meroni1, Ahmad Qasem3, 4, Mark Butlin3, Julian Ayer1, 5, David Celermajer1, 2, Alberto Avolio3, Michael Skilton1
1University of Sydney, Sydney, Australia
2Royal Prince Alfred Hospital, Sydney, Australia
3Macquarie University, Sydney, Australia
4AtCor Medical, Sydney, Australia
5The Children’s Hospital at Westmead, Sydney, Australia
Available Online 17 February 2020.
DOI
10.2991/artres.k.191224.159How to use a DOI?
Abstract

Background: Arterial stiffness is a significant cardiovascular risk factor. Carotid-femoral pulse wave velocity (cfPWV) is the standard for measuring arterial stiffness, but indices such as central augmentation index (cAIx) and carotid artery elasticity (cE[p]) also correlate to arterial stiffness. Early-life determinants of arterial stiffening are not well understood. We assessed the relationship between population-indexed anthropometric and hemodynamic parameters, and arterial stiffness in healthy children.

Methods: 97 healthy children between 2 to 20 years old were recruited. Z-scores for height, BMI, and brachial systolic (bSBP) and diastolic (bDBP) blood pressure were calculated [1,2]. cfPWV and central arterial waveforms were measured using the Sphygmocor XCEL and CvMS devices (AtCor, Sydney) respectively. Carotid artery maximum and minimum diameters were measured by high-resolution ultrasonography. cfPWV, cE[p], and cAIx were calculated.

Results: In bivariate analysis, cfPWV was associated with age (b = 0.52, p < 0.01) and bSBP z-score (b = 0.24, p = 0.03). These associations were independent of sex, height z-score, BMI z-score, and bDBP z-score in a multivariable model (R2 = 0.23). cE[p] was significantly associated with age (b = 0.42, p < 0.01), bSBP z-score (b = 0.45, p < 0.01), and height z-score (b = −0.33, p = 0.01), but only bSBP z-score remained statistically significant in the multivariable model (b = 0.45, p < 0.01; R2 = 0.20). cAIx was not associated with anthropometric or hemodynamic z-scores.

Conclusion: cfPWV is associated with age and bSBP z-score, while cE[p] is associated with bSBP z-score only, suggesting a potentially key association between systolic blood pressure and indices of arterial stiffness independent of age and other parameters of growth during healthy early life.

Copyright
© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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<Previous Article In Issue
Next Article In Issue>
Journal
Artery Research
Volume-Issue
25 - Supplement 1
Pages
S174 - S174
Publication Date
2020/02/17
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.2991/artres.k.191224.159How to use a DOI?
Copyright
© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - JOUR
AU  - Tommy Cai
AU  - Alice Meroni
AU  - Ahmad Qasem
AU  - Mark Butlin
AU  - Julian Ayer
AU  - David Celermajer
AU  - Alberto Avolio
AU  - Michael Skilton
PY  - 2020
DA  - 2020/02/17
TI  - P136 Determinants of Arterial Stiffness in Children Using Population-indexed Anthropometric and Hemodynamic Parameters
JO  - Artery Research
SP  - S174
EP  - S174
VL  - 25
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.191224.159
DO  - 10.2991/artres.k.191224.159
ID  - Cai2020
ER  -