3.5 ASSOCIATION OF VASCULAR RISK FACTORS WITH BRAIN STRUCTURE AND FUNCTION

DOI

10.1016/j.artres.2015.10.018How to use a DOI?

Abstract

Background: Vascular risk factors have been associated with brain aging. We aimed to determine the associations between blood pressure (BP), atherosclerosis, arterial stiffness and microvascular damage with both structural and functional measures of the brain.

Methods: A community-based sample of 1287 individuals (69 ± 6 yrs) underwent cognitive function testing and MRI to measure hippocampal brain volumes. Brachial and central systolic BP (SBP, cSBP) and pulse pressure (PP, cPP), diastolic BP (DBP), arterial stiffness (cfPWV), atherosclerosis (cIMT) and microvascular disease (composite from retinopathy, ACR and eGFR measures) were measured.

Results: After adjusting for age, sex and ethnicity hippocampal volume was significantly associated with SBP (β ± SE: −0.004 ± 0.002; p = 0.01), PP (β ± SE: −0.008 ± 0.002; p < 0.0001), cPP(β ± SE: −0.01 ± 0.003; p < 0.0001) and cfPWV (β ± SE: −0.02 ± 0.01; p = 0.04). Cognitive function (z-score) was significantly associated with PP (β ± SE: −0.004 ± 0.002; p = 0.003) and cPP (β ± SE: −0.005 ± 0.002; p = 0.02). After further adjustment for concomitant risk factors (heart-rate, diabetes, hypertension, previous stroke, coronary artery disease, waist-to-hip ratio, years of education and smoking) only the associations with PP (Hippocampal volume β ± SE: −0.005 ± 0.002; p = 0.02, cognitive function β ± SE: −0.004 ± 0.001; p = 0.01) and cPP (Hippocampal volume β ± SE: −0.008 ± 0.003; p = 0.004, cognitive function β ± SE: −0.004 ± 0.002; p = 0.048) remained significant.

Conclusion: In this community based sample brachial and central PP were significantly associated with measures of brain structure and function, not explained by concomitant risk factors.

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TY  - JOUR
AU  - Chloe Park*
AU  - Therese Tillin
AU  - Robert Stewart
AU  - Nish Chaturvedi
AU  - Alun Hughes
PY  - 2015
DA  - 2015/11/23
TI  - 3.5 ASSOCIATION OF VASCULAR RISK FACTORS WITH BRAIN STRUCTURE AND FUNCTION
JO  - Artery Research
SP  - 43
EP  - 43
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.018
DO  - 10.1016/j.artres.2015.10.018
ID  - Park*2015
ER  -