3.4 EVALUATION OF THE MUTUAL RELATIONSHIPS AMONG THE DEVELOPMENT OF HYPERTENSION, ARTERIAL STIFFENING AND RENAL FUNCTION DECLINE BASED ON REPEATED LONGITUDINAL MEASUREMENTS

DOI

10.1016/j.artres.2015.10.017How to use a DOI?

Abstract

Background: The mechanisms underlying the development of hypertension have not yet been fully clarified. The mutual relationships among the development of hypertension and the longitudinal changes of arterial stiffness and renal function, and also the effect of maintenance of a normal body weight on these relationships were evaluated by a linear mixed-effects regression model analysis (LMM).

Methods and Results: In 3932 middle-aged Japanese subjects without hypertension (41 ± 9 years old), an 11-year prospective observational study was conducted by repeated annual measurements of the blood pressure (BP), brachial-ankle pulse wave velocity (baPWV), and serum creatinine-derived estimated glomerular filtration rate (eGFR). The mean number of measurements per patient was 6.5. The LMM analysis revealed that higher values of the baPWV were associated with annual elevation of the SBP, and higher values of the SBP were associated with annual increase of the baPWV (estimate = 0.2103, p < 0.001). These associations were also significant in the subjects in whom the body mass index was maintained at <25.0 at the end of observation period (n = 2815). However, no significant relationships were observed between the eGFR/proteinuria and the annual change of the baPWV/BP.

Conclusions: The results of LMM analysis in this study revealed that, while a vicious cycle may exist between the development of hypertension and the progression of arterial stiffening, mild renal dysfunction as reflected by eGFR decline and/or proteinuria may not affect this vicious cycle. Furthermore, maintenance of a normal body weight may not be effective for interrupting this vicious cycle.

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TY  - JOUR
AU  - Hirofumi Tomiyama*
AU  - Akira Yamashina
PY  - 2015
DA  - 2015/11/23
TI  - 3.4 EVALUATION OF THE MUTUAL RELATIONSHIPS AMONG THE DEVELOPMENT OF HYPERTENSION, ARTERIAL STIFFENING AND RENAL FUNCTION DECLINE BASED ON REPEATED LONGITUDINAL MEASUREMENTS
JO  - Artery Research
SP  - 43
EP  - 43
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.017
DO  - 10.1016/j.artres.2015.10.017
ID  - Tomiyama*2015
ER  -