P7.12 PULSE PRESSURE AND INTIMA MEDIA THICKNESS IN RELATION TO SERUM VITAMIN D CONCENTRATION IN A SAMPLE OF GENERAL POPULATION

Agata Franczyk*; Katarzyna Stolarz-Skrzypek; Agnieszka Olszanecka; Wiktoria Wojciechowska; Anna Wesoαowska; Kalina Kawecka-Jaszcz; Danuta Czarnecka

doi:10.1016/j.artres.2015.10.315

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Volume 12, Issue C, December 2015, Pages 32 - 32

P7.12 PULSE PRESSURE AND INTIMA MEDIA THICKNESS IN RELATION TO SERUM VITAMIN D CONCENTRATION IN A SAMPLE OF GENERAL POPULATION

Authors

Agata Franczyk*¹, Katarzyna Stolarz-Skrzypek², Agnieszka Olszanecka², Wiktoria Wojciechowska², Anna Wesoαowska¹, Kalina Kawecka-Jaszcz², Danuta Czarnecka²

¹Department of Clinical Pharmacy, Jagiellonian University Medical College, Krakow, Poland

²Ist Department of Cardiology, Interventional Electrocardiology and Hypertension, Jagiellonian University Medical College, Krakow, Poland

Available Online 23 November 2015.

DOI: 10.1016/j.artres.2015.10.315 How to use a DOI?
Abstract: Objectives: Vitamin D regulates the renin-angiotensin-aldosterone system, inhibits proliferation of cardiomyocytes and vascular smooth muscles and has anti-inflammatory effects. We aimed to investigate the relation between serum vitamin D concentration and arterial structure and function in a sample of general population.

Methods: The study group included 303 subjects recruited from general population. Office BP was measured at 2 separate visits, 5 times at each visit. SpaceLabs90207 oscillometric monitors were programmed to measure ambulatory BP (ABP) each 15 min. daytime (6.00 – 22.00) and each 30 min. nighttime. Ultrasound examination of carotid arteries allowed to obtain the intima media thickness(IMT). Based on the ABP data, we calculated pulse pressure (PP) over 24h, daytime and nighttime. Vitamin D concentration was measured in serum. Database management and multivariate analyses were performed with SAS software (SAS Institute, Cary, NC, version9.3).

Results: The study group included 138 men and 165 women, mean age = 47 ± 16 years, 164 subjects had hypertension. Mean serum vitamin D level was 21.1±8.7 ng/ml. With adjustments applied for age, sex, body mass index, 24-hour systolic blood pressure and smoking, serum vitamin D negatively correlated with 24h PP (beta=−0,05±0,038, p=0,05) and daytime PP (beta=−0,035±0,027, p=0,05). We observed positive correlation between IMT and vitamin D in two subgroups: in younger population (mean age=34,8yrs, beta=0,01±0,019, p=0,03) and in male participants(beta=0,0012±0,052, p=0,03).

Conclusion: In that general population, vitamin D concentration was negatively associated with 24 h and daytime pulse pressure. Higher cholecalciferol was related to intima media thickness but only in men and in young individuals.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 12 - C
Pages: 32 - 32
Publication Date: 2015/11/23
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2015.10.315 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - Agata Franczyk*
AU  - Katarzyna Stolarz-Skrzypek
AU  - Agnieszka Olszanecka
AU  - Wiktoria Wojciechowska
AU  - Anna Wesoαowska
AU  - Kalina Kawecka-Jaszcz
AU  - Danuta Czarnecka
PY  - 2015
DA  - 2015/11/23
TI  - P7.12 PULSE PRESSURE AND INTIMA MEDIA THICKNESS IN RELATION TO SERUM VITAMIN D CONCENTRATION IN A SAMPLE OF GENERAL POPULATION
JO  - Artery Research
SP  - 32
EP  - 32
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.315
DO  - 10.1016/j.artres.2015.10.315
ID  - Franczyk*2015
ER  -

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