Artery Research

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Volume 12, Issue C, December 2015, Pages 32 - 33

P7.13 RELATION OF PARAMETERS OF VASCULAR STIFFNESS TO CARDIAC STRUCTURE AND FUNCTION IN PATIENTS AT RISK OF OR WITH TYPE 2 DIABETES

Authors
Luca Faconti*1, 3, Charlotte E. Mills1, 3, Virginia Govoni1, 3, Maria L. Casagrande1, 3, Andrew J. Webb2, 3, Kennedy J. Cruickshank1, 3
1King’s College London, Division of Diabetes and Nutritional Sciences, London, UK
2King’s College London, British Heart Foundation Centre, Cardiovascular Division, Department of Clinical Pharmacology, London, UK
3Guy’s and St Thomas’ NHS Foundation Trust, NIHR Biomedical Research Centre, London, UK
Available Online 23 November 2015.
DOI
10.1016/j.artres.2015.10.316How to use a DOI?
Abstract

Objective: To investigate the relationship between arterial function and cardiac, especially left ventricular (LV) diastolic, function, in people at risk of or with type 2 diabetes (T2DM).

Design and method: 64 patients (48% non-European) participated in the study. Cardiac indices were obtained by 2-dimensional echocardiography, aortic pulse wave velocity (PWV) and augmentation index (AIx) were measured with an Arteriograph, cardio ankle vascular index (CAVI), nominally independent of pressure, was obtained using a VaSera device.

Results: Mean age was 59 y, 83% with T2DM, 84% hypertension, 12% previous cardiovascular events. Regressions for AIx with LV mass index (mean 51.2 g/m2.7) and left atrium volume index (β(SE)) were 0.52 (0.16) and 1.43 (0.4), p<0.002. Tissue Doppler indices (TDI) of diastolic function, E′ septal and E′ lateral waves were inversely related with AIx (−2.94 (0.9) and −2.14 (0.8)) as they were with CAVI (left, −0.2 (0.07) and −0.27 (0.05)) (all p<0.01), but the E/E′ ratio was not. Similarly, TDI for systolic function, S′, was related with AIx (−3.7 (1.1)) and with CAVI (0.21 (0.1))(p<0.05). In multiple regression models these relationships were still significant, when including age, gender, BMI, diabetic status and ethnicity, for cardiac structure and function (p<0.05), as with CAVI measures (p<0.05). There was no relationship with aortic PWV.

Conclusion: In patients at risk of or with T2DM, pressure augmentation is related to cardiac remodeling and diastolic function while a mainly pressure-independent index of stiffness of the aorta, femoral and tibial artery (CAVI) is associated with TDI of diastolic function.

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<Previous Article In Issue
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Journal
Artery Research
Volume-Issue
12 - C
Pages
32 - 33
Publication Date
2015/11/23
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2015.10.316How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Luca Faconti*
AU  - Charlotte E. Mills
AU  - Virginia Govoni
AU  - Maria L. Casagrande
AU  - Andrew J. Webb
AU  - Kennedy J. Cruickshank
PY  - 2015
DA  - 2015/11/23
TI  - P7.13 RELATION OF PARAMETERS OF VASCULAR STIFFNESS TO CARDIAC STRUCTURE AND FUNCTION IN PATIENTS AT RISK OF OR WITH TYPE 2 DIABETES
JO  - Artery Research
SP  - 32
EP  - 33
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.316
DO  - 10.1016/j.artres.2015.10.316
ID  - Faconti*2015
ER  -