P7.1 INCREASED PLATELET REACTIVITY IS RESPONSIBLE OF MODIFICATIONS OF THROMBIN GENERATION IN PATIENTS WITH UNCONTROLLED ARTERIAL HYPERTENSION

Jeremy Lagrange*; Yvonne Weihert; Susanne Karbach; Philip Wenzel

doi:10.1016/j.artres.2015.10.305

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Volume 12, Issue C, December 2015, Pages 29 - 30

P7.1 INCREASED PLATELET REACTIVITY IS RESPONSIBLE OF MODIFICATIONS OF THROMBIN GENERATION IN PATIENTS WITH UNCONTROLLED ARTERIAL HYPERTENSION

Authors

Jeremy Lagrange*¹, Yvonne Weihert¹, Susanne Karbach¹^{, 2}, Philip Wenzel¹^{, 2}

¹Center for Thrombosis and Hemostasis, Mainz, Germany

²Department of Medicine 2 University Medical Center, Mainz, Germany

Available Online 23 November 2015.

DOI: 10.1016/j.artres.2015.10.305 How to use a DOI?
Abstract: Background: Hypertensive crisis is an extreme phenotype of increased blood pressure that can lead to organs failure and thrombotic complications. Recently, we were able to show an angiotensin II driven FXI-thrombin amplification loop leading to vascular injury in experimental hypertension.

Objective: The aim of this study was to evaluate the thrombin generation (TG) in patients with uncontrolled arterial hypertension (AHt).

Patients and methods: We prospectively examined 27 patients with uncontrolled AHt at the emergency department of the medical center of Mainz, and 26 age match controls. TG was measured by calibrated automated thrombography (CAT) in platelet rich and platelet poor plasma (PRP/PPP).

Results: AHt patients had an increased systolic blood pressure, compared to control patients (182±10.7 versus 134±9.6 mmHg); age, BMI and weight were not different. Unexpectedly, CAT assay performed in PPP showed a decreased of TG in uncontrolled AHt patients (1269±55 versus 1444±51 nM.min) as well as a decrease in the peak of generation. The TG performed in PRP was identical between uncontrolled AHt and control patients (1550±65 versus 1513±58 nM.min), but the peak of generation, as well as the velocity, were increased in uncontrolled AHt patients. In both groups, TG was reduced by blocking the apple 3 domain of FXI, indicating an involvement of the FXI thrombin loop in thrombin generation in PRP of uncontrolled AHt patients.

Conclusion: These results point out the important role of platelet overreactivity in hypertension. Monitoring the prothrombotic state of platelets might add to risk stratification of patients with AHt.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 12 - C
Pages: 29 - 30
Publication Date: 2015/11/23
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2015.10.305 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - Jeremy Lagrange*
AU  - Yvonne Weihert
AU  - Susanne Karbach
AU  - Philip Wenzel
PY  - 2015
DA  - 2015/11/23
TI  - P7.1 INCREASED PLATELET REACTIVITY IS RESPONSIBLE OF MODIFICATIONS OF THROMBIN GENERATION IN PATIENTS WITH UNCONTROLLED ARTERIAL HYPERTENSION
JO  - Artery Research
SP  - 29
EP  - 30
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.305
DO  - 10.1016/j.artres.2015.10.305
ID  - Lagrange*2015
ER  -

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