P6.20 ROLE OF ALTERED VASCULAR REACTIVITY IN THE PATHOPHYSIOLOGY OF ACUTE MOUNTAIN SICKNESS

Rosa Maria Bruno*; Guido Giardini; Sandro Malacrida; Bruna Catuzzo; Sabina Armenia; Lorenzo Ghiadoni; Raffaele Brustia; Paolo Laveder; Paolo Salvi; Emmanuel Cauchy; Lorenza Pratali

doi:10.1016/j.artres.2015.10.304

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Volume 12, Issue C, December 2015, Pages 29 - 29

P6.20 ROLE OF ALTERED VASCULAR REACTIVITY IN THE PATHOPHYSIOLOGY OF ACUTE MOUNTAIN SICKNESS

Authors

Rosa Maria Bruno*¹, Guido Giardini³, Sandro Malacrida², Bruna Catuzzo³, Sabina Armenia⁴, Lorenzo Ghiadoni⁴, Raffaele Brustia⁵, Paolo Laveder², Paolo Salvi⁶, Emmanuel Cauchy⁷, Lorenza Pratali¹

¹Institute of Clinical Physiology, CNR, Pisa, Italy

²University of Padua, Padua, Italy

³Valle d’Aosta Regional Hospital, Aosta, Italy

⁴University of Pisa, Pisa, Italy

⁵Hôpital Saint-Antoine, Paris, France

⁶Istituto Auxologico Italiano, Milan, Italy

⁷IFREMMONT, Chamonix, France

Available Online 23 November 2015.

DOI: 10.1016/j.artres.2015.10.304 How to use a DOI?
Abstract: Purpose: The aim of this study is to explore the physiological vascular adaptation to exposure to high altitude and to test the hypothesis that its impairment might play a role in the pathophysiology of acute mountain sickness (AMS).

Methods: 34 healthy volunteers (age 38±11years, 13 women) were studied at the sea-level and after passive ascent to 3842 m (Aguille du Midi, France). Blood pressure (BP), O2 saturation (SO2), endothelial function (flow-mediated dilation, FMD), carotid distensibility coefficient (DC), carotid-femoral pulse wave velocity (PWV), peak systolic velocity in the middle cerebral artery (MCA-PSV) were performed at sea level (T0) and after 4-h hypobaric hypoxia (T1). AMS was defined as a Lake-Louise Score>5 after 24-h hypobaric hypoxia (T2).

Results: At T2 12 individuals developed AMS (AMS+). AMS+ had a greater SO2 worsening at T1 as compared to AMS- (AMS+: 97.2±1.2 to 79.3±5.8%; AMS-: 97.3±1.2 to 83.1 ± 5.7%, p=0.03), with similar heart rate increase and unchanged BP. FMD was significantly reduced in AMS+ (5.75±3.01 to 3.27±1.87%, p=0.04), but not in AMS- (4.74±2.47 to 4.02±2.36%). Mean carotid diameter was increased at T1 in both groups. DC tended to be increased in AMS- but not in AMS+, while PWV was unchanged. MCA-PSV was increased in AMS-, but not in AMS+.

Conclusions: In healthy asymptomatic individuals exposed to high altitude, conduit artery endothelial function is preserved in the cerebral district vasodilatation, increased elasticity and blood flow occurs. This compensatory response is early blunted in AMS+, before symptoms onset, thus suggesting a pathogenetic role.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 12 - C
Pages: 29 - 29
Publication Date: 2015/11/23
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2015.10.304 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - Rosa Maria Bruno*
AU  - Guido Giardini
AU  - Sandro Malacrida
AU  - Bruna Catuzzo
AU  - Sabina Armenia
AU  - Lorenzo Ghiadoni
AU  - Raffaele Brustia
AU  - Paolo Laveder
AU  - Paolo Salvi
AU  - Emmanuel Cauchy
AU  - Lorenza Pratali
PY  - 2015
DA  - 2015/11/23
TI  - P6.20 ROLE OF ALTERED VASCULAR REACTIVITY IN THE PATHOPHYSIOLOGY OF ACUTE MOUNTAIN SICKNESS
JO  - Artery Research
SP  - 29
EP  - 29
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.304
DO  - 10.1016/j.artres.2015.10.304
ID  - Bruno*2015
ER  -

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