Artery Research

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Volume 12, Issue C, December 2015, Pages 28 - 28

P6.16 LEFT VENTRICULAR GEOMETRY AND CAROTID VASCULAR DAMAGE IN PATIENTS UNDERGOING CORONARY ANGIOGRAPHY

Authors
M. Salvetti*1, A. Paini1, M.F. Cesana2, A. Moreo3, R. Facchetti2, P. Faggiano8, S. Carerj4, G.F. Mureddu5, N. Gaibazzi6, F. Rigo7, C. Giannattasio2, 3, M.L. Muiesan1
1Internal Medicine, University of Brescia, Italy
2Department Scienze della Salute, Bicocca University, Milano, Italy
3Department Cardiovascolare De Gasperi, Bicocca University, Milano, Italy
4Cardiology, University of Messina, Italy
5Hospital San Giovanni-Addolorata, Rome, Italy
6University of Parma, Parma, Italy
7Cardiology, Ospedale dell’Angelo, Mestre-Venezia, Italy
8Cardiology, University of Brescia, Italy
Available Online 23 November 2015.
DOI
10.1016/j.artres.2015.10.300How to use a DOI?
Abstract

Background: Vascular structural(intima-media thickness, IMT) and functional(carotid stiffness, cPWV)alterations are related to different pattern of left ventricular (LV) geometry in general populations and in hypertensives. The relationship between vascular damage and LV geometry has not been analyzed prospectively in patients undergoing coronary angiography.

Methods: 399 consecutive patients with clinical indication to coronary angiography, prospectively underwent standard ultrasound examination for the evaluation of LV mass index(LVMi g/m2.7), relative wall thickness(RWT), distal anterior descending coronary artery flow velocity(LADd_vel), carotid ultrasound with real time echotracking system for measurement of central blood pressure(cSBP, cDBP), common carotid intima media thickness(cIMT) and carotid pulse wave velocity(cPWV) (Esaote MyLab 70). The noninvasive evaluations were performed blindly to clinical information, before coronary angiography.

Results: cIMT and cPWV were higher in patients with concentric LVH(LVMI≥49 g/h2.7 in men and ≥47 g/h2.7 in women and RWT≥ 0.42) as compared to N (normal LV mass and geometry) and CR (concentric remodeling, normal LVMi and RWT>0.42). LADd_vel was greater in patients with concentric LVH than in others groups. The prevalence of coronary stenosis(>50%) was greater in patients with concentric LVH and CR as compared to N. Patients with concentric geometry (RWT≥0.42) showed higher values of cIMT(773±169 vs 729±162, p<0.005), cPWV(8.9±2.7 vs 9.6±2.6, p<0.05) and LADd_vel(40±22 vs 48±31, p<0.05) and a greater prevalence of coronary stenosis(>50%)than patients with RWT<0.42(53 vs 69%, p<0.005).

Conclusions: Our results confirm that in patients undergoing coronary angiography concentric geometry in associated with structural and functional carotid alterations, with increased central blood pressure and anterior descending coronary artery flow velocity. In this large group of patients, concentric geometry is associated with a greater prevalence of coronary stenosis, as assessed by coronary angiography.

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<Previous Article In Issue
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Journal
Artery Research
Volume-Issue
12 - C
Pages
28 - 28
Publication Date
2015/11/23
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2015.10.300How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

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risenwbib
TY  - JOUR
AU  - M. Salvetti*
AU  - A. Paini
AU  - M.F. Cesana
AU  - A. Moreo
AU  - R. Facchetti
AU  - P. Faggiano
AU  - S. Carerj
AU  - G.F. Mureddu
AU  - N. Gaibazzi
AU  - F. Rigo
AU  - C. Giannattasio
AU  - M.L. Muiesan
PY  - 2015
DA  - 2015/11/23
TI  - P6.16 LEFT VENTRICULAR GEOMETRY AND CAROTID VASCULAR DAMAGE IN PATIENTS UNDERGOING CORONARY ANGIOGRAPHY
JO  - Artery Research
SP  - 28
EP  - 28
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.300
DO  - 10.1016/j.artres.2015.10.300
ID  - Salvetti*2015
ER  -