P6.15 ATTENUATION OF ARTERIAL STIFFNESS GRADIENT WITH AGE AND ITS IMPACT ON CENTRAL PULSE WAVE PROFILE IN DIALYSIS PATIENTS

Catherine Fortier; Marie-Pier Desjardins; David Turgeon; Karine Marquis; Marcel Lebel; Mohsen Agharazii*

doi:10.1016/j.artres.2015.10.299

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Volume 12, Issue C, December 2015, Pages 28 - 28

P6.15 ATTENUATION OF ARTERIAL STIFFNESS GRADIENT WITH AGE AND ITS IMPACT ON CENTRAL PULSE WAVE PROFILE IN DIALYSIS PATIENTS

Authors

Catherine Fortier¹^{, 2}, Marie-Pier Desjardins¹^{, 2}, David Turgeon¹^{, 2}, Karine Marquis², Marcel Lebel², Mohsen Agharazii*¹^{, 2}

¹Université Laval, Québec, QC, Canada

²Chu de Québec Research Center, Québec, QC, Canada

Available Online 23 November 2015.

DOI: 10.1016/j.artres.2015.10.299 How to use a DOI?
Abstract: Background: Arterial stiffness has been considered as an index of vascular ageing. However, the relationship between age and stiffness of various segments of the arterial tree is heterogeneous. Moreover, the hemodynamic impact of vascular stiffness is thought to be related to the attenuation or even reversal of the physiological arterial stiffness gradient. The objectives of the present study were to evaluate the impact of age on aortic (central elastic artery) and brachial (muscular conduit artery) stiffness and to assess hemodynamic correlates of the arterial stiffness gradient.

Method/results: In 310 dialysis patients (67 years [25^th-75^thpercentiles: 56–76], 185(60%) men, 134(43%) diabetes and 162(52%) cardiovascular disease), we measured aortic and brachial stiffness by pulse wave velocity of carotid-femoral (cf-PWV) and carotid-radial (cr-PWV) using direct distances (Complior). Arterial stiffness gradient was determined by cf-PWV/cr-PWV (PWV ratio). Central pulse wave parameters were obtained through generalized transfer function applied to the radial artery pulse profile (Sphygmocor). Mean cf-PWV, cr-PWV and PWV ratio were respectively of 13.52 ±4.07m/s, 8.76 ±1.68m/s and 1.59 ±0.52m/s. Cr-PWV decreased with age (β=−0.031, R=−0.274, P0.001), while cf-PWV (β=0.144, R=0.529, P0.001) and PWV ratio (β=0.021, R=0.613, P0.001) increased. In contrast to cf-PWV and cr-PWV, PWV ratio was not associated with MBP (P=0.997).

Conclusion: The use of PWV ratio may be a more logical choice for risk determination than aortic stiffness as it provides a better estimation of the loss of arterial stiffness gradient and is not influenced by MBP in this population.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 12 - C
Pages: 28 - 28
Publication Date: 2015/11/23
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2015.10.299 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - Catherine Fortier
AU  - Marie-Pier Desjardins
AU  - David Turgeon
AU  - Karine Marquis
AU  - Marcel Lebel
AU  - Mohsen Agharazii*
PY  - 2015
DA  - 2015/11/23
TI  - P6.15 ATTENUATION OF ARTERIAL STIFFNESS GRADIENT WITH AGE AND ITS IMPACT ON CENTRAL PULSE WAVE PROFILE IN DIALYSIS PATIENTS
JO  - Artery Research
SP  - 28
EP  - 28
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.10.299
DO  - 10.1016/j.artres.2015.10.299
ID  - Fortier2015
ER  -

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