Artery Research

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Volume 16, Issue C, December 2016, Pages 72 - 72

10.6 VARIATION OF THE ASYMPTOTIC DIASTOLIC PRESSURE WITH DIFFERENT FITTING TECHNIQUES IN HEALTHY HUMANS

Authors
Nicola Pomella1, Christina Kolyva3, Ernst Rietzschel2, Patrick Segers2, Ashraf W. Khir1, Madalina Negoita1
1Brunel University, London, UK
2Universiteit Gent, Belgium
3Middlesex University, London, UK
Available Online 24 November 2016.
DOI
10.1016/j.artres.2016.10.084How to use a DOI?
Abstract

Background: Reservoir-wave model assumes the measured pressure (Pm) consists of two additive components: reservoir (Pr) and excess pressure (Pex)1–2. Calculation of Pr requires fitting the diastolic decay of Pm for calculating parameters P∞ (asymptotical value) and b (time constant)1. However, there is no consensus over the value of these parameters1–3–4. Although many investigators use free-fitting, different degrees of freedom (dof) could be used1–2–5. The aim of this study was to examine the effect of varying fitting method on P∞ ,b and calculate the peaks of Pr and Pex.

Methods: Pressure data from common carotid artery of 505 middle-aged healthy subjects were selected from the Asklepios dataset. Free-fitting methods with 3 dof (dicrotic notch not fixed) and 2 dof (dicrotic notch fixed) were used to obtain P∞ , b and calculate Pr and Pex.

Results: Mean value of P∞ change significantly between 3 dof and 2 dof (58 vs. 50 mmHg p<0.01) as well as b (2.3 vs. 1.9 s−1 p<0.01). Pr- and Pex- peaks didn’t significantly change (Pr= 105 mmHg for 3 dof and 2 dof p>0.05 Pex = 30 mmHg and 31 mmHg for 3 dof and 2 dof, respectively p>0.05).

Conclusions: P∞ and b values are method-dependent with a large variation between methods. P∞ values in our study are higher than previously reported in literature, and variation in P∞ and b values don’t affect Pr- and Pex- peaks. Given the variability in the combination of P∞ ,b in different subjects, the use of free-fitting is more appropriate.

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<Previous Article In Issue
Next Article In Issue>
Journal
Artery Research
Volume-Issue
16 - C
Pages
72 - 72
Publication Date
2016/11/24
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2016.10.084How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Nicola Pomella
AU  - Christina Kolyva
AU  - Ernst Rietzschel
AU  - Patrick Segers
AU  - Ashraf W. Khir
AU  - Madalina Negoita
PY  - 2016
DA  - 2016/11/24
TI  - 10.6 VARIATION OF THE ASYMPTOTIC DIASTOLIC PRESSURE WITH DIFFERENT FITTING TECHNIQUES IN HEALTHY HUMANS
JO  - Artery Research
SP  - 72
EP  - 72
VL  - 16
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2016.10.084
DO  - 10.1016/j.artres.2016.10.084
ID  - Pomella2016
ER  -