4.2 WITHDRAWAL OF STATINS THERAPY IN PATIENTS AFTER CAROTID ENDARTERECTOMY ASSOCIATED WITH INCREASING RISK OF SIGNIFICANT RESTENOSIS

DOI

10.1016/j.artres.2016.10.021How to use a DOI?

Abstract

Background: The benefit of carotid revascularization is decreased by the occurrence of restenosis at the site of surgery, which is associated with a modestly increased risk of stroke. Preventing restenosis plays pivotal role in the overall treatment and prevention of stroke in patients with carotid artery disease.

Purpose: To evaluate influence of discontinuing of statins therapy on occurrence of restenosis in patients after carotid endarterectomy.

Methods: We studied 240 patients after carotid endarterectomy, mean age – 64.4±6.8 years. All the patients were divided into two groups: 1 group comprised 124 patients, who had taken atorvastatin in dose 10–40 mg daily and 2 group – 116 patients who discontinued statins therapy due complication 3 %, poor tolerance 9% or personal reluctance 88%. All the patients also underwent serial standardized ultrasound examination on 1, 3, 6, 12 month during first year after operation and then annually. Mean observation time was 5.6±2.1 years. Significant restenosis carotid artery (more than 70%) was established by standard Doppler velocity criteria.

Results: The significant restenosis of internal carotid artery was found in 2,4% patients with statins therapy and in 7,8% patients without statins. Statins withdrawal increased the incidence of late significant restenosis of internal carotid artery (odd ratio: 3.393 95% confidence interval: 0.895–12.857). Patients with withdrawal of statins had higher wall thickness: 4.3±0.8 against 2.9±0.9 (#1088 p<0,05).

Conclusion: Withdrawal of statins therapy in patients after carotid endarterectomy associated with increasing risk of significant restenosis carotid artery.

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TY  - JOUR
AU  - Olga Tereshina
AU  - Alexcey Vachev
PY  - 2016
DA  - 2016/11/24
TI  - 4.2 WITHDRAWAL OF STATINS THERAPY IN PATIENTS AFTER CAROTID ENDARTERECTOMY ASSOCIATED WITH INCREASING RISK OF SIGNIFICANT RESTENOSIS
JO  - Artery Research
SP  - 54
EP  - 54
VL  - 16
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2016.10.021
DO  - 10.1016/j.artres.2016.10.021
ID  - Tereshina2016
ER  -