Artery Research

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Volume 16, Issue C, December 2016, Pages 50 - 50

2.5 THE EFFECT OF RENAL DENERVATION ON CENTRAL BLOOD PRESSURE AND ARTERIAL STIFFNESS IN TREATMENT RESISTANT ESSENTIAL HYPERTENSION: A SUBSTUDY OF A RANDOMIZED SHAM-CONTROLLED DOUBLE-BLINDED TRIAL (THE RESET TRIAL)

Authors
Christian D. Peters1, Ole N. Mathiasen2, Henrik Vase2, Jesper Bech3, Kent L. Christensen2, Anne P. Schroeder4, Ole Lederballe4, Hans Rickers5, Ulla Kampmann6, Per L. Poulsen6, Sten Langfeldt7, Gratien Andersen7, Klavs W. Hansen8, Hans E. Bøtker2, Morten Engholm2, Jannik B. Bertelsen2, Jens F. Lassen2, Erling B. Pedersen3, Anne Kaltoft2, Niels H. Buus9
1Department of Renal Medicine, Aarhus University Hospital, Aarhus, Denmark
2Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark
3University Clinic in Nephrology and Hypertension, Holstebro Hospital, Hostelbro, Denmark
4Department of Cardiology, Viborg Hospital, Viborg, Denmark
5Department of Cardiology, Randers Hospital, Randers, Denmark
6Department of Endocrinology, Aarhus University Hospital, NBG, Aarhus, Denmark
7Department of Radiology, Aarhus University Hospital, Skejby, Aarhus, Denmark
8Department of Internal Medicine, Silkeborg Hospital, Silkeborg, Denmark
9Department of Nephrology, Aalborg University Hospital, Aalborg, Denmark
Available Online 24 November 2016.
DOI
10.1016/j.artres.2016.10.009How to use a DOI?
Abstract

Background: A recent sham-controlled trial (ReSET) showed no sustained effect of renal denervation (RDN) on 24-hour ambulatory blood pressure (24hA-BP) measurements in patients with treatment resistant hypertension.1 The aim of this substudy was to investigate, whether RDN affects central blood pressure (C-BP) and arterial stiffness independently of brachial artery BP-levels.

Methods: ReSET was a randomized, sham-controlled, double-blinded single-center trial. Main inclusion criteria were: daytime systolic 24hA-BP ≥145mmHg following 1 month of stable medication and 2 weeks of compliance registration. RDN was performed by a single experienced operator using the unipolar Medtronic Flex catheter1. C-BP and carotid-femoral pulse wave velocity (PWV) were obtained at baseline and after 6 months with the SphygmoCor®-device.

Results: Fifty-three patients (77% of the ReSET cohort) were included in this substudy. The groups were similar at baseline (SHAM/RDN): n=27/n=26; 78/65% males; age 59±9/54±8 years (mean±SD); systolic brachial BP 158±18/154±17 mmHg; systolic 24hA-BP 153±14/151±13 mmHg; systolic C-BP 146±20/143±17 mmHg; diastolic C-BP 92±14/94±10 mmHg; augmentation index (AIx) 26±9/28±13 %; PWV 10.7±2.1/10.1±2.2 m/s. Changes in systolic C-BP (−2±17 (SHAM) vs. −8±16 (RDN) mmHg), diastolic C-BP (−2±9 (SHAM) vs. −5±9 (RDN) mmHg), AIx (0.7±7.0 (SHAM) vs. 1.0±7.4 (RDN) %), and PWV (0.1±1.9 (SHAM) vs. −0.6±1.3 (RDN) m/s) were not significantly different after six months (P>0.13 in all tests). Changes in brachial BP and 24hA-BP were also not significantly different.

Conclusions: In a sham-controlled setting, there were no significant effects of RDN on C-BP or arterial stiffness. Thus, the idea of BP-independent effects of RDN on large arteries is not supported.

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Journal
Artery Research
Volume-Issue
16 - C
Pages
50 - 50
Publication Date
2016/11/24
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2016.10.009How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Christian D. Peters
AU  - Ole N. Mathiasen
AU  - Henrik Vase
AU  - Jesper Bech
AU  - Kent L. Christensen
AU  - Anne P. Schroeder
AU  - Ole Lederballe
AU  - Hans Rickers
AU  - Ulla Kampmann
AU  - Per L. Poulsen
AU  - Sten Langfeldt
AU  - Gratien Andersen
AU  - Klavs W. Hansen
AU  - Hans E. Bøtker
AU  - Morten Engholm
AU  - Jannik B. Bertelsen
AU  - Jens F. Lassen
AU  - Erling B. Pedersen
AU  - Anne Kaltoft
AU  - Niels H. Buus
PY  - 2016
DA  - 2016/11/24
TI  - 2.5 THE EFFECT OF RENAL DENERVATION ON CENTRAL BLOOD PRESSURE AND ARTERIAL STIFFNESS IN TREATMENT RESISTANT ESSENTIAL HYPERTENSION: A SUBSTUDY OF A RANDOMIZED SHAM-CONTROLLED DOUBLE-BLINDED TRIAL (THE RESET TRIAL)
JO  - Artery Research
SP  - 50
EP  - 50
VL  - 16
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2016.10.009
DO  - 10.1016/j.artres.2016.10.009
ID  - Peters2016
ER  -