Artery Research

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Volume 20, Issue C, December 2017, Pages 102 - 102

P150 ARTERIAL STIFFNESS AND PROGRESSION OF CEREBRAL WHITE MATTER LESIONS IN ASYMPTOMATIC PATIENTS WITH TYPE 2 DIABETES AND MATCHED CONTROLS: A 5-YEAR COHORT STUDY

Authors
Kristian Løkke Funck1, Esben Laugesen1, Pernille Høyem1, Brian Stausbøll-Grøn2, Won Kim3, 2, Leif Østergaard4, Dora Zeidler4, Troels Krarup Hansen1, Per Løgstrup Poulsen1
1Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Denmark
2MR Research Centre, Department of Clinical Medicine, Aarhus University, Denmark
3Department of Cardiology, Aarhus University Hospital, Denmark
4Center of Functionally Integrative Neuroscience, Aarhus University Hospital, Denmark
Available Online 6 December 2017.
DOI
10.1016/j.artres.2017.10.171How to use a DOI?
Abstract

Aim: Stroke is a frequent and feared complication in patients with type 2 diabetes. Arterial stiffness may improve current suboptimal risk prediction of stroke. However, studies in diabetes populations are lacking. We investigated the association between arterial stiffness progression (carotid-femoral pulse wave velocity [PWV]) and the progression of cerebral white matter lesions (WML), a marker of stroke risk, in patients with type 2 diabetes and matched controls.

Methods: In a 5-year follow-up study, data from 49 patients and 58 controls were available for analysis. At baseline, participants had a mean (±SD) age of 59±10 years and patients had a median (range) diabetes duration of 1.8 (1.0–3.2) years. Fifty-two (49%) were males. At both baseline and follow-up, PWV was obtained by tonometry and WML by cerebral T2-FLAIR MRI. WML was assessed by Breteler score, and progression was defined as an upward change in category during follow-up.

Results: Patients with type 2 diabetes had a higher PWV than controls at both baseline (9.2±2.2 vs. 7.9±1.4m/s, p < 0.01) and follow-up (9.8±2.4 vs. 8.6±1.9m/s, p = 0.01). Breteler scores and WML progression were similar in the two groups (p > 0.05). PWV progression was associated with WML progression in the total cohort (adjusted for age, sex, diabetes, baseline PWV and systolic blood pressure progression: OR 1.58 [95%CI: 1.09–2.28], p = 0.02). We found no interaction between diabetes and PWV progression on WML progression.

Conclusions: PWV progression is associated with WML progression in patients with type 2 diabetes and healthy controls. PWV candidates as a new risk marker for stroke.

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<Previous Article In Issue
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Journal
Artery Research
Volume-Issue
20 - C
Pages
102 - 102
Publication Date
2017/12/06
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2017.10.171How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Kristian Løkke Funck
AU  - Esben Laugesen
AU  - Pernille Høyem
AU  - Brian Stausbøll-Grøn
AU  - Won Kim
AU  - Leif Østergaard
AU  - Dora Zeidler
AU  - Troels Krarup Hansen
AU  - Per Løgstrup Poulsen
PY  - 2017
DA  - 2017/12/06
TI  - P150 ARTERIAL STIFFNESS AND PROGRESSION OF CEREBRAL WHITE MATTER LESIONS IN ASYMPTOMATIC PATIENTS WITH TYPE 2 DIABETES AND MATCHED CONTROLS: A 5-YEAR COHORT STUDY
JO  - Artery Research
SP  - 102
EP  - 102
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.171
DO  - 10.1016/j.artres.2017.10.171
ID  - Funck2017
ER  -