P150 ARTERIAL STIFFNESS AND PROGRESSION OF CEREBRAL WHITE MATTER LESIONS IN ASYMPTOMATIC PATIENTS WITH TYPE 2 DIABETES AND MATCHED CONTROLS: A 5-YEAR COHORT STUDY

Kristian Løkke Funck; Esben Laugesen; Pernille Høyem; Brian Stausbøll-Grøn; Won Kim; Leif Østergaard; Dora Zeidler; Troels Krarup Hansen; Per Løgstrup Poulsen

doi:10.1016/j.artres.2017.10.171

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Volume 20, Issue C, December 2017, Pages 102 - 102

P150 ARTERIAL STIFFNESS AND PROGRESSION OF CEREBRAL WHITE MATTER LESIONS IN ASYMPTOMATIC PATIENTS WITH TYPE 2 DIABETES AND MATCHED CONTROLS: A 5-YEAR COHORT STUDY

Authors

Kristian Løkke Funck¹, Esben Laugesen¹, Pernille Høyem¹, Brian Stausbøll-Grøn², Won Kim³^{, 2}, Leif Østergaard⁴, Dora Zeidler⁴, Troels Krarup Hansen¹, Per Løgstrup Poulsen¹

¹Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Denmark

²MR Research Centre, Department of Clinical Medicine, Aarhus University, Denmark

³Department of Cardiology, Aarhus University Hospital, Denmark

⁴Center of Functionally Integrative Neuroscience, Aarhus University Hospital, Denmark

Available Online 6 December 2017.

DOI: 10.1016/j.artres.2017.10.171 How to use a DOI?
Abstract: Aim: Stroke is a frequent and feared complication in patients with type 2 diabetes. Arterial stiffness may improve current suboptimal risk prediction of stroke. However, studies in diabetes populations are lacking. We investigated the association between arterial stiffness progression (carotid-femoral pulse wave velocity [PWV]) and the progression of cerebral white matter lesions (WML), a marker of stroke risk, in patients with type 2 diabetes and matched controls.

Methods: In a 5-year follow-up study, data from 49 patients and 58 controls were available for analysis. At baseline, participants had a mean (±SD) age of 59±10 years and patients had a median (range) diabetes duration of 1.8 (1.0–3.2) years. Fifty-two (49%) were males. At both baseline and follow-up, PWV was obtained by tonometry and WML by cerebral T2-FLAIR MRI. WML was assessed by Breteler score, and progression was defined as an upward change in category during follow-up.

Results: Patients with type 2 diabetes had a higher PWV than controls at both baseline (9.2±2.2 vs. 7.9±1.4m/s, p < 0.01) and follow-up (9.8±2.4 vs. 8.6±1.9m/s, p = 0.01). Breteler scores and WML progression were similar in the two groups (p > 0.05). PWV progression was associated with WML progression in the total cohort (adjusted for age, sex, diabetes, baseline PWV and systolic blood pressure progression: OR 1.58 [95%CI: 1.09–2.28], p = 0.02). We found no interaction between diabetes and PWV progression on WML progression.

Conclusions: PWV progression is associated with WML progression in patients with type 2 diabetes and healthy controls. PWV candidates as a new risk marker for stroke.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 20 - C
Pages: 102 - 102
Publication Date: 2017/12/06
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2017.10.171 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - Kristian Løkke Funck
AU  - Esben Laugesen
AU  - Pernille Høyem
AU  - Brian Stausbøll-Grøn
AU  - Won Kim
AU  - Leif Østergaard
AU  - Dora Zeidler
AU  - Troels Krarup Hansen
AU  - Per Løgstrup Poulsen
PY  - 2017
DA  - 2017/12/06
TI  - P150 ARTERIAL STIFFNESS AND PROGRESSION OF CEREBRAL WHITE MATTER LESIONS IN ASYMPTOMATIC PATIENTS WITH TYPE 2 DIABETES AND MATCHED CONTROLS: A 5-YEAR COHORT STUDY
JO  - Artery Research
SP  - 102
EP  - 102
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.171
DO  - 10.1016/j.artres.2017.10.171
ID  - Funck2017
ER  -

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