P28 DETERMINANTS OF ARTERIAL STIFFNESS AS MARKER OF EARLY VASCULAR AGING IN PHYSICIANS POPULATION

DOI

10.1016/j.artres.2017.10.168How to use a DOI?

Abstract

Objective: To analyze determinants of arterial stiffness in physician’s population.

Methods: Observational multicenter study of doctor’s vascular health conducted in 12 Russian cities (VICTORIA study). Demographics; smoking status; anamnesis of arterial hypertension (AH) with/without therapy, medications, established CV, renal diseases, diabetes mellitus; cholesterol and glucose level were registered. Arterial stiffness and vascular age was assessed using BPLab® device with Vasotens® technology (Petr Telegin Company, Nizhny Novgorod, Russia). Arterial stiffness was defined as an elevation of pulse pressure (PP) > 60 mmHg, PWV > 10 m/s.

Results: 464 individuals were included (247 normotensives (mean age 44 yrs) and 237 with AH (mean age 58 yrs)). Mean PP was 46.0±9.8 mm Hg in normotensive group and 58.6±17.4 mm Hg in group with AH (p < 0.001). Mean PWVao was 10.9±2.0 m/s and 12.5±2.5 m/s in groups without and with AH, respectively (p < 0.001). PP > 60 mm Hg had 11% subjects without AH and 43% with elevated blood pressure (BP) (p < 0.001). PWVao >10 m/s had 68% of normotensive subjects and 92% of hypertensive patients (p < 0.001). PWVao correlated with brachial systolic (r = 0,42, p < 0.05) and diastolic BP (r = 0,38; p < 0.05), central systolic (r = 0,45, p < 0.05) and diastolic BP (r = 0,41; p < 0.05), age (r = 0,37, p < 0.05), heart rate (r = 0,41, p < 0.05). There was association between elevated PWVao and body mass index (r = 0,39, p < 0.05). In a multiple linear regression model, independent determinants of PWV were systolic BP (β = 0,29, p < 0.001), body mass index (β = 0,19, p < 0.001).

Conclusions: High PWVao measured by BPLab® device with Vasotens® technology is characterized physician’s population with and without AH. The main determinants of PWVao are systolic BP and body mass index.

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TY  - JOUR
AU  - Elena Shavarova
AU  - Eldar Kazahmedov
AU  - Artemiy Orlov
AU  - Zhanna Kobalava
PY  - 2017
DA  - 2017/12/06
TI  - P28 DETERMINANTS OF ARTERIAL STIFFNESS AS MARKER OF EARLY VASCULAR AGING IN PHYSICIANS POPULATION
JO  - Artery Research
SP  - 101
EP  - 101
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.168
DO  - 10.1016/j.artres.2017.10.168
ID  - Shavarova2017
ER  -