P28 DETERMINANTS OF ARTERIAL STIFFNESS AS MARKER OF EARLY VASCULAR AGING IN PHYSICIANS POPULATION

DOI

10.1016/j.artres.2017.10.168How to use a DOI?

Abstract

Objective: To analyze determinants of arterial stiffness in physician’s population.

Methods: Observational multicenter study of doctor’s vascular health conducted in 12 Russian cities (VICTORIA study). Demographics; smoking status; anamnesis of arterial hypertension (AH) with/without therapy, medications, established CV, renal diseases, diabetes mellitus; cholesterol and glucose level were registered. Arterial stiffness and vascular age was assessed using BPLab® device with Vasotens® technology (Petr Telegin Company, Nizhny Novgorod, Russia). Arterial stiffness was defined as an elevation of pulse pressure (PP) > 60 mmHg, PWV > 10 m/s.

Results: 464 individuals were included (247 normotensives (mean age 44 yrs) and 237 with AH (mean age 58 yrs)). Mean PP was 46.0±9.8 mm Hg in normotensive group and 58.6±17.4 mm Hg in group with AH (p < 0.001). Mean PWVao was 10.9±2.0 m/s and 12.5±2.5 m/s in groups without and with AH, respectively (p < 0.001). PP > 60 mm Hg had 11% subjects without AH and 43% with elevated blood pressure (BP) (p < 0.001). PWVao >10 m/s had 68% of normotensive subjects and 92% of hypertensive patients (p < 0.001). PWVao correlated with brachial systolic (r = 0,42, p < 0.05) and diastolic BP (r = 0,38; p < 0.05), central systolic (r = 0,45, p < 0.05) and diastolic BP (r = 0,41; p < 0.05), age (r = 0,37, p < 0.05), heart rate (r = 0,41, p < 0.05). There was association between elevated PWVao and body mass index (r = 0,39, p < 0.05). In a multiple linear regression model, independent determinants of PWV were systolic BP (β = 0,29, p < 0.001), body mass index (β = 0,19, p < 0.001).

Conclusions: High PWVao measured by BPLab® device with Vasotens® technology is characterized physician’s population with and without AH. The main determinants of PWVao are systolic BP and body mass index.

Open Access

This is an open access article distributed under the CC BY-NC license.

TY  - JOUR
AU  - Elena Shavarova
AU  - Eldar Kazahmedov
AU  - Artemiy Orlov
AU  - Zhanna Kobalava
PY  - 2017
DA  - 2017/12/06
TI  - P28 DETERMINANTS OF ARTERIAL STIFFNESS AS MARKER OF EARLY VASCULAR AGING IN PHYSICIANS POPULATION
JO  - Artery Research
SP  - 101
EP  - 101
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.168
DO  - 10.1016/j.artres.2017.10.168
ID  - Shavarova2017
ER  -