P113 DIASTOLIC AMBULATORY BLOOD PRESSURE PARAMETERS ARE ASSOCIATED WITH VALVE CALCIFICATION IN PATIENTS WITH END-STAGE RENAL DISEASE ON MAINTENANCE HEMODIALYSIS

DOI

10.1016/j.artres.2017.10.144How to use a DOI?

Abstract

Objective: Valve calcification (VC) is common in patients on hemodialysis and increases the risk of cardiovascular morbidity and mortality. The aim if the study was to evaluate the association between VC and 44-hour ambulatory blood pressure (ABP) variables.

Materials and methods: In 68 patients with end-stage renal disease (ESRD) on maintenance hemodialysis (45.6% males, median age 58.3 (interquartile range (IQR) 54.6; 61.6) years, dialysis duration 62.7 (47.8; 77) months, arterial hypertension 94%, heart failure 28%, diabetes mellitus 21%, glomerulonephritis 35%, pyelonephritis 25%, multicystic dysplastic kidney 13%) echocardiography and 44-hour ABP monitoring was performed. Mann-Whitney test was considered significant if p < 0.05.

Results: Calcification of the aortic (AVC), mitral (MVC) and both valves was revealed in 46 (67.6%), 34 (50%) and 33 (48.5%) of patients. 20 (29%) patients had no signs of VC. Patients with vs without AVC had lower daytime diastolic BP (DBP) (79±13 vs 89±12 mmHg, p < 0.01), nighttime DBP (75±13 vs 83±13 mmHg, p < 0.05), day one DBP (77±13 vs 89±15 mmHg, p < 0.01), day two DBP (79±14 vs 88±10 mmHg, p < 0.01), 44-hour DBP (78±13 vs 88±12 mmHg, p < 0.01).

Patients with vs without MVC had lower daytime DBP (78±15 vs 86±11 mmHg, p < 0.01), nighttime DBP (74±14 vs 81±12 mmHg, p < 0.05), 44-hour DBP (77±15 vs 85±11 mmHg, p < 0.01), higher daytime DBP variability (10±3 vs 9±3 mmHg, p < 0.01).

Conclusion: High prevalence of valve calcification (71%) was revealed in patients with ESRD on hemodialysis. Patients with VC were older, had higher duration of dialysis, lower values of ambulatory DBP.

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TY  - JOUR
AU  - Maria Trukhanova
AU  - Nadezhda Manukhina
AU  - Dmitry Doroshenko
AU  - Svetlana Villevalde
AU  - Zhanna Kobalava
PY  - 2017
DA  - 2017/12/06
TI  - P113 DIASTOLIC AMBULATORY BLOOD PRESSURE PARAMETERS ARE ASSOCIATED WITH VALVE CALCIFICATION IN PATIENTS WITH END-STAGE RENAL DISEASE ON MAINTENANCE HEMODIALYSIS
JO  - Artery Research
SP  - 93
EP  - 93
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.144
DO  - 10.1016/j.artres.2017.10.144
ID  - Trukhanova2017
ER  -