P46 ARTERIAL STIFFNESS IN RELATION TO BIRTH CHARACTERISTICS IN THE JAMAICAN 1986 BIRTH COHORT

Nadia Bennett; Trevor Ferguson; Novie Younger-Coleman; Marshall Tulloch-Reid; Renee Walters; Amanda Rousseau; Janeil Williams; Seeromanie Harding; J. Kennedy Cruickshank; Rainford Wilks

doi:10.1016/j.artres.2017.10.074

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Volume 20, Issue C, December 2017, Pages 68 - 68

P46 ARTERIAL STIFFNESS IN RELATION TO BIRTH CHARACTERISTICS IN THE JAMAICAN 1986 BIRTH COHORT

Authors

Nadia Bennett¹, Trevor Ferguson², Novie Younger-Coleman², Marshall Tulloch-Reid², Renee Walters², Amanda Rousseau², Janeil Williams², Seeromanie Harding³, J. Kennedy Cruickshank³, Rainford Wilks²

¹King’s College, London, UK

²Caribbean Institute for Health Research, The University of the West Indies, Mona, Kingston, Jamaica

³Diabetes and Nutritional Sciences Division, School of Medicine, Kings College, London, UK

Available Online 6 December 2017.

DOI: 10.1016/j.artres.2017.10.074 How to use a DOI?
Abstract: Background: We tested the association between birthweight and arterial stiffness measured by aortic pulse wave velocity (PWV) and cardio-ankle vascular index (CAVI) in a birth cohort of 30 year old Jamaicans.

Methods: Participants were from the 1986 Jamaica Birth Cohort. Arterial stiffness was measured as PWV using Arteriograph 24h^TM and CAVI with VaSera^TM devices. Current anthropometry (height, weight, waist and hip circumference), and brachial blood pressure measures were linked to birthweight and other early life markers of

CVD risk (birth-length and maternal height). Linear regression models were used for analysis.

Results: Analyses included 235 participants 44% male, with mean±SD age 29.8±0.7years, birthweight 3.1±0.0kg, PWV 6.3±0.1m/s and CAVI 6.3±0.1. Bivariate models showed men had higher arterial stiffness (p < 0.001). Maternal height (p = 0.031), waist/hip ratio (p = 0.019), BMI (p = <0.001) and blood pressure (systolic and diastolic) (p < 0.001) were associated with PWV, but only BMI (p < 0.001) was associated with CAVI. There was no association between birthweight and PWV or CAVI, p = 0.38 and p = 0.41 respectively. In multivariable models, associations between birthweight and PWV and CAVI did not change after controlling for gender, BMI, and SBP. Positive associations (coef±SE) between PWV and BMI (0.03±0.01 p = <0.01) and SBP (0.03±0.01 p = 0.001) remained significant; as did the negative associations for BMI and CAVI (−0.04±0.01 p < 0.001).

Conclusion: Men had higher arterial stiffness even when controlling for blood pressure and the associations of blood pressure and BMI with PWV were positive whereas and BMI with CAVI was negative. Neither arterial stiffness measure was associated with birthweight.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 20 - C
Pages: 68 - 68
Publication Date: 2017/12/06
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2017.10.074 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - Nadia Bennett
AU  - Trevor Ferguson
AU  - Novie Younger-Coleman
AU  - Marshall Tulloch-Reid
AU  - Renee Walters
AU  - Amanda Rousseau
AU  - Janeil Williams
AU  - Seeromanie Harding
AU  - J. Kennedy Cruickshank
AU  - Rainford Wilks
PY  - 2017
DA  - 2017/12/06
TI  - P46 ARTERIAL STIFFNESS IN RELATION TO BIRTH CHARACTERISTICS IN THE JAMAICAN 1986 BIRTH COHORT
JO  - Artery Research
SP  - 68
EP  - 68
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.074
DO  - 10.1016/j.artres.2017.10.074
ID  - Bennett2017
ER  -

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