P4 SOCIAL STRESS-INDUCED BLOOD PRESSURE INCREASE IN BORDERLINE HYPERTENSIVE RATS IS ASSOCIATED WITH ENDOTHELIAL DYSFUNCTION IN THE RESISTANT ARTERIES

Angelika Puzserova; Ruzena Sotnikova; Jozef Torok; Anna Zemancikova; Iveta Bernatova

doi:10.1016/j.artres.2017.10.057

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Volume 20, Issue C, December 2017, Pages 62 - 63

P4 SOCIAL STRESS-INDUCED BLOOD PRESSURE INCREASE IN BORDERLINE HYPERTENSIVE RATS IS ASSOCIATED WITH ENDOTHELIAL DYSFUNCTION IN THE RESISTANT ARTERIES

Authors

Angelika Puzserova¹, Ruzena Sotnikova², Jozef Torok¹, Anna Zemancikova¹, Iveta Bernatova¹

¹Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, Slovak Republic

²Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, Slovak Republic

Available Online 6 December 2017.

DOI: 10.1016/j.artres.2017.10.057 How to use a DOI?
Abstract: Objectives: Several studies have observed that altered endothelial function is involved in the development of stress-induced hypertension. The aim of this study was to investigate the effects of chronic social stress (crowding) on endothelium-dependent relaxation (EDR) of the superior mesenteric artery (SMA) and of small resistant mesenteric arteries (MA) as well as on neurogenic contractions of SMA in adult borderline hypertensive rats (BHR).

Methods: Twelve-week-old BHR (offspring of spontaneously hypertensive dams and Wistar-Kyoto sires) males were exposed to crowding (living space: 200 cm²/rat) for eight weeks. Control BHR were kept in the groups of four rats per cage (living space: 480 cm²/rat). Systolic blood pressure (sBP) was determined by the tail-cuff method.

Vascular function was investigated in the isolated arteries at isometric conditions.

EDR was assessed using acetylcholine test.

Results: Crowding significantly increased sBP of BHR to the hypertensive values. Results showed that stress did not affect total acetylcholine-induced relaxation and its nitric oxide (NO)-dependent and NO-independent components in the SMA. In the resistant MA, stress reduced total acetylcholine-induced relaxation by reducing NO-independent component, without the alterations of its NO-dependent component.

However, stress failed to affect significantly neurogenic contractions of SMA elicited by electrical stimulation of perivascular sympathetic nerves and vasoconstriction induced by exogenous noradrenaline in SMA.

Conclusion: In conclusion, chronic social stress can accelerate the development of hypertension in BHR, which seems to be associated with NO-independent endothelial dysfunction in small resistant arteries.

Supported by the grants VEGA No. 2/0190/17 and APVV-16-0263.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 20 - C
Pages: 62 - 63
Publication Date: 2017/12/06
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2017.10.057 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - Angelika Puzserova
AU  - Ruzena Sotnikova
AU  - Jozef Torok
AU  - Anna Zemancikova
AU  - Iveta Bernatova
PY  - 2017
DA  - 2017/12/06
TI  - P4 SOCIAL STRESS-INDUCED BLOOD PRESSURE INCREASE IN BORDERLINE HYPERTENSIVE RATS IS ASSOCIATED WITH ENDOTHELIAL DYSFUNCTION IN THE RESISTANT ARTERIES
JO  - Artery Research
SP  - 62
EP  - 63
VL  - 20
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2017.10.057
DO  - 10.1016/j.artres.2017.10.057
ID  - Puzserova2017
ER  -

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