P95 BLOOD PRESSURE VARIABILITY, ARTERIAL STIFFNESS AND ARTERIAL REMODELING – THE MAASTRICHT STUDY
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- 10.1016/j.artres.2018.10.148How to use a DOI?
- Abstract
Greater very short- to mid-term blood pressure variability (BPV) has been associated with an increased CVD risk, especially stroke. However, this link remains incompletely understood. We hypothesized that increased arterial stiffness and maladaptive carotid arterial remodeling may underlie this association. We therefore investigated the association between very short- to mid-term systolic BPV, aortic and carotid stiffness and carotid arterial remodeling using cross-sectional data from The Maastricht Study (aged 60 ± 8 years; 53% men). Aortic (carotid-femoral pulse wave velocity, n = 1671) and carotid stiffness (ultrasonography, n = 1690) were assessed. A composite index of systolic BPV was derived by standardizing and averaging systolic within-visit, 24-hour, and 7-day BPV. We performed linear regression analyses with adjustment for age, sex, glucose metabolism status, mean arterial pressure and cardiovascular risk factors. A 1-SD greater systolic BPV was statistically significantly associated with 0.10 m/s (95%CI: 0.01 – 0.20) greater cfPWV, but not with carotid distensibility (−0.033·10-3/kPa [−0.255 – 0.190]). In addition, a 1-SD greater systolic BPV was statistically significantly associated with greater carotid circumferential wall tension (0.84 dyne/cm [0.51 – 1.17]), circumferential wall stress (0.79 kPa [0.031 – 1.27]) and intima-media thickness (8.6 μm [1.0 – 16.3]). These results are indicative of maladaptive carotid remodeling, as circumferential wall tension and stress were not normalized despite greater intima-media thickness. In conclusion, greater very short- to mid-term BPV is associated with greater aortic stiffness and maladaptive carotid arterial remodeling, but not with carotid stiffness. These findings may explain, at least partially, the increased BPV-associated CVD risk, in particular stroke.
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TY - JOUR AU - Tan Lai Zhou AU - Ronald Henry AU - Coen Stehouwer AU - Thomas van Sloten AU - Koen Reesink AU - Abraham Kroon PY - 2018 DA - 2018/12/04 TI - P95 BLOOD PRESSURE VARIABILITY, ARTERIAL STIFFNESS AND ARTERIAL REMODELING – THE MAASTRICHT STUDY JO - Artery Research SP - 106 EP - 106 VL - 24 IS - C SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2018.10.148 DO - 10.1016/j.artres.2018.10.148 ID - Zhou2018 ER -