P95 BLOOD PRESSURE VARIABILITY, ARTERIAL STIFFNESS AND ARTERIAL REMODELING – THE MAASTRICHT STUDY

DOI

10.1016/j.artres.2018.10.148How to use a DOI?

Abstract

Greater very short- to mid-term blood pressure variability (BPV) has been associated with an increased CVD risk, especially stroke. However, this link remains incompletely understood. We hypothesized that increased arterial stiffness and maladaptive carotid arterial remodeling may underlie this association. We therefore investigated the association between very short- to mid-term systolic BPV, aortic and carotid stiffness and carotid arterial remodeling using cross-sectional data from The Maastricht Study (aged 60 ± 8 years; 53% men). Aortic (carotid-femoral pulse wave velocity, n = 1671) and carotid stiffness (ultrasonography, n = 1690) were assessed. A composite index of systolic BPV was derived by standardizing and averaging systolic within-visit, 24-hour, and 7-day BPV. We performed linear regression analyses with adjustment for age, sex, glucose metabolism status, mean arterial pressure and cardiovascular risk factors. A 1-SD greater systolic BPV was statistically significantly associated with 0.10 m/s (95%CI: 0.01 – 0.20) greater cfPWV, but not with carotid distensibility (−0.033·10-3/kPa [−0.255 – 0.190]). In addition, a 1-SD greater systolic BPV was statistically significantly associated with greater carotid circumferential wall tension (0.84 dyne/cm [0.51 – 1.17]), circumferential wall stress (0.79 kPa [0.031 – 1.27]) and intima-media thickness (8.6 μm [1.0 – 16.3]). These results are indicative of maladaptive carotid remodeling, as circumferential wall tension and stress were not normalized despite greater intima-media thickness. In conclusion, greater very short- to mid-term BPV is associated with greater aortic stiffness and maladaptive carotid arterial remodeling, but not with carotid stiffness. These findings may explain, at least partially, the increased BPV-associated CVD risk, in particular stroke.

Open Access

This is an open access article distributed under the CC BY-NC license.

TY  - JOUR
AU  - Tan Lai Zhou
AU  - Ronald Henry
AU  - Coen Stehouwer
AU  - Thomas van Sloten
AU  - Koen Reesink
AU  - Abraham Kroon
PY  - 2018
DA  - 2018/12/04
TI  - P95 BLOOD PRESSURE VARIABILITY, ARTERIAL STIFFNESS AND ARTERIAL REMODELING – THE MAASTRICHT STUDY
JO  - Artery Research
SP  - 106
EP  - 106
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.148
DO  - 10.1016/j.artres.2018.10.148
ID  - Zhou2018
ER  -