Artery Research

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Volume 6, Issue 2, June 2012, Pages 97 - 102

Increased aortic wave reflection and longitudinal regional diastolic dysfunction in patients with left ventricular hypertrophy

Authors
Joji Ishikawaa, *, Yoshio Matsuib, Cesare Russoc, Eiichi Hyodoc, Kotaro Araic, Marco R. DiTulioc, Shunichi Hommac, Kazuomi Karioa
aDivision of Cardiovascular Medicine, Department of Internal Medicine, Jichi Medical University School of Medicine, 3311-1Yakushiji, Shimotsuke, Tochigi 329-0498, Japan
bIwakuni Medical Center, Yamaguchi, Japan
cDepartment of Cardiology, Columbia University Medical Center, New York, NY, USA
*Corresponding author. Tel.: +81 285 58 7344; fax: +81 285 44 5317. E-mail address: george@jichi.ac.jp (J. Ishikawa).
Corresponding Author
Joji Ishikawa
Received 1 September 2011, Revised 20 December 2011, Accepted 4 January 2012, Available Online 23 January 2012.
DOI
10.1016/j.artres.2012.01.002How to use a DOI?
Keywords
Radial augmentation index; Left ventricular hypertrophy; Tissue Doppler imaging; Strain; Strain rate
Abstract

Objectives: Increased arterial stiffness is associated with the progression of left ventricular hypertrophy (LVH); however, the endocardial layer (End) contracts more than the epicardial layer (Epi), and it is unclear whether increased arterial stiffness affects regional wall deformation in both the End and Epi in LVH.

Methods: We performed echocardiography and measured the radial augmentation index (rAIx) in 41 patients with LVH. We evaluated the longitudinal strain, and early diastolic strain rate (SRdia) (measures of regional wall deformation) in both End and Epi in addition to measures of global diastolic function. The ratios of End strain to Epi strain (End/Epi strain) and End SRdia to Epi SRdia (End/Epi SRdia) were also calculated.

Results: All of the patients had a decreased LV diastolic function (E/e′>8) and preserved ejection fraction (>45%). The rAIx was slightly related to the End/Epi SRdia (r=0.29, P=0.063); the relationship of rAIx to End/Epi SRdia (beta=0.52, P=0.034) was significant after adjustment for potential confounding factors. The rAIx at heart rate 75 beats per minute (rAIx@HR75) was significantly related to End/Epi SRdia (r=0.36, P=0.023); the relationship of rAIx@HR75 to End/Epi SRdia remained significant even after the adjustment (P=0.032). The relationships of rAIx@HR75 to End/Epi strain did not reach the level of statistical significance (r=0.30, P=0.06) in this study.

Conclusion: Increased rAIx, a measure of aortic wave reflection, may be associated with a regional diastolic function in the ratio of endocardial to epicardial layer of the left ventricular wall in patients with left ventricular hypertrophy.

Copyright
© 2012 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

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<Previous Article In Issue
Next Article In Issue>
Journal
Artery Research
Volume-Issue
6 - 2
Pages
97 - 102
Publication Date
2012/01/23
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2012.01.002How to use a DOI?
Copyright
© 2012 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Joji Ishikawa
AU  - Yoshio Matsui
AU  - Cesare Russo
AU  - Eiichi Hyodo
AU  - Kotaro Arai
AU  - Marco R. DiTulio
AU  - Shunichi Homma
AU  - Kazuomi Kario
PY  - 2012
DA  - 2012/01/23
TI  - Increased aortic wave reflection and longitudinal regional diastolic dysfunction in patients with left ventricular hypertrophy
JO  - Artery Research
SP  - 97
EP  - 102
VL  - 6
IS  - 2
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2012.01.002
DO  - 10.1016/j.artres.2012.01.002
ID  - Ishikawa2012
ER  -