Relationship between 24 h ambulatory central blood pressure and left ventricular mass – Rationale and design of a prospective multicenter study

Thomas Weber; Carmel McEniery; Ian Wilkinson; Giuseppe Schillaci; Maria Lorenza Muiesan; Robert Zweiker; Cristina Giannattasio; Kai Mortensen; Johannes Baulmann; Arno Schmidt-Trucksäss; Siegfried Wassertheurer

doi:10.1016/j.artres.2012.01.001

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Volume 6, Issue 2, June 2012, Pages 103 - 108

Relationship between 24 h ambulatory central blood pressure and left ventricular mass – Rationale and design of a prospective multicenter study

Authors

Thomas Weber^a^{, *}, Carmel McEniery^b, Ian Wilkinson^b, Giuseppe Schillaci^c, Maria Lorenza Muiesan^d, Robert Zweiker^e, Cristina Giannattasio^f, Kai Mortensen^g, Johannes Baulmann^g, Arno Schmidt-Trucksäss^h, Siegfried Wassertheurerⁱ

^aCardiology Department, Klinikum Wels-Grieskirchen, Grieskirchnerstrasse 42, 4600 Wels, Austria

^bClinical Pharmacology Unit, University of Cambridge, UK

^cUnit of Internal Medicine, Angiology and Arteriosclerosis, University of Perugia, Italy

^dDepartment of Medical and Surgical Sciences, University of Brescia, Italy

^eCardiology Department, Medical University Graz, Austria

^fDirettore Scuola di Specializzazione in Malattie Cardiovascolari, Università di Milano Bicocca, Italy

^gCardiology Department, University of Lübeck, Germany

^hInstitute of Exercise and Health Sciences, University of Basel, Switzerland

ⁱAustrian Institute of Technology, Vienna, Austria

^*Corresponding author. Tel.: +43 7242 415 2215; fax: +43 7242 415 3992. E-mail address: thomas.weber3@liwest.at (T. Weber).

Corresponding Author

Thomas Weber

Received 22 October 2011, Revised 23 December 2011, Accepted 4 January 2012, Available Online 20 January 2012.

DOI: 10.1016/j.artres.2012.01.001 How to use a DOI?
Keywords: Central blood pressure; Ambulatory blood pressure monitoring; Left ventricular mass
Abstract: The prognostic superiority of ambulatory over clinic blood pressure has been repeatedly proven. However, due to the mechanical properties of the arterial system, systolic and pulse pressures are higher in the brachial artery than in the ascending aorta. It seems logical that central pressures are more relevant to cardiovascular disease than peripheral (brachial) pressures, and indeed, using clinic blood pressures, it has been shown that central systolic and pulse pressures are more closely associated with hypertensive end-organ damage than their brachial counterparts. Moreover, antihypertensive drugs can have differential effects on central versus brachial blood pressures. All these effects have been described on the basis of clinic blood pressure measurements. Recent advances in technology allow the estimation of central systolic blood pressure from brachial pulse waves recorded with a regular brachial oscillometric blood-pressure cuff, using a transfer-function like algorithm (ARCSolver). This method has been invasively validated and allows the recording of 24 h ambulatory central blood pressure profiles. Our multicenter study now aims for the first time to investigate the relationship between central ambulatory blood pressure monitoring and hypertensive end-organ damage (left ventricular mass) in untreated adults.
Open Access: This is an open access article distributed under the CC BY-NC license.

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<Previous Article In Issue

Journal: Artery Research
Volume-Issue: 6 - 2
Pages: 103 - 108
Publication Date: 2012/01/20
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2012.01.001 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - Thomas Weber
AU  - Carmel McEniery
AU  - Ian Wilkinson
AU  - Giuseppe Schillaci
AU  - Maria Lorenza Muiesan
AU  - Robert Zweiker
AU  - Cristina Giannattasio
AU  - Kai Mortensen
AU  - Johannes Baulmann
AU  - Arno Schmidt-Trucksäss
AU  - Siegfried Wassertheurer
PY  - 2012
DA  - 2012/01/20
TI  - Relationship between 24 h ambulatory central blood pressure and left ventricular mass – Rationale and design of a prospective multicenter study
JO  - Artery Research
SP  - 103
EP  - 108
VL  - 6
IS  - 2
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2012.01.001
DO  - 10.1016/j.artres.2012.01.001
ID  - Weber2012
ER  -

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