Artery Research

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Volume 3, Issue 4, December 2009, Pages 170 - 170

P4.02 EFFECTS OF TOCOLYTICAL MEDICATION ON BLOOD PRESSURE AND BLOOD PRESSURE AMPLIFICATION

Authors
I.G.M. Fabry2, P. De Paepe1, L. Van Bortel1
1Heymans Institute of Pharmacology, Ghent University, B-9000 Ghent, Belgium
2Drug Research Unit Ghent, Ghent University Hospital, B-9000 Ghent, Belgium
Available Online 3 December 2009.
DOI
10.1016/j.artres.2009.10.043How to use a DOI?
Abstract

Objective: Atosiban (oxytocin-antagonist) and ritodrine (β-agonist) are frequently used tocolytics. Only a few studies investigated the hemodynamic effects of atosiban. We therefore aimed to study the effects on the blood pressure (BP) and BP-amplification.

Methods: Twenty healthy female volunteers (19–41 yrs) were given atosiban (300 μg/min over 2h) and placebo intravenously (IV) in a random crossover design. Eight of them also received ritodrine IV in escalating doses up to 400μg/min over 2h. The brachial artery (BA) blood pressures (BP) were taken by an oscillometric device (OMRON 705-IT) and the BP at the common carotid artery (CCA) and the radial artery (RA) were calculated using applanation tonometry. This was done at the steady state of the highest dose. Statistical analysis was done using Friedman and Wilcoxon test setting value of significance at 0.05.

Results: Effects on atosiban/placebo on N=20 did not differ from N=8.

Parameters (mmHg) Ritodrine (n=8) Atosiban (n=8) Placebo (n=8) p-value$
SBPCCA 113±13*# 105±10 100±6 0.012
SBPBA 114±13*# 106±10 103±6 0.004
SBPRA 115±15*# 110±13 110±7 0.368
DBPBA 55±11*# 69±6 68±5 0.008
MAP 76±10*# 84±8 82±6 <0.001

SBP (systolic BP), DBP (diastolic BP), MAP (mean arterial pressure).

$

Friedman-test;

*

significant vs. atosiban,

#

significant vs. placebo.

Conclusion: The data show increased SBP at the CCA and BA and lower DBP and MAP under ritodrine. The effects of atosiban did not differ from placebo. Although not statistically significant, the data suggest a nearly absent pressure amplification between CCA-RA during ritodrine administration.

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<Previous Article In Issue
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Journal
Artery Research
Volume-Issue
3 - 4
Pages
170 - 170
Publication Date
2009/12/03
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2009.10.043How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - I.G.M. Fabry
AU  - P. De Paepe
AU  - L. Van Bortel
PY  - 2009
DA  - 2009/12/03
TI  - P4.02 EFFECTS OF TOCOLYTICAL MEDICATION ON BLOOD PRESSURE AND BLOOD PRESSURE AMPLIFICATION
JO  - Artery Research
SP  - 170
EP  - 170
VL  - 3
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2009.10.043
DO  - 10.1016/j.artres.2009.10.043
ID  - Fabry2009
ER  -