H. pylori-induced higher C-reactive protein in obese African Americans

Nuzhat R. Siddiqui; W. Timothy Garvey; Mohammad A. Khaled

doi:10.1016/j.artres.2009.01.004

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Volume 3, Issue 1, February 2009, Pages 39 - 42

H. pylori-induced higher C-reactive protein in obese African Americans

Authors

Nuzhat R. Siddiqui^a, W. Timothy Garvey^a^{, b}, Mohammad A. Khaled^a^{, *}

^aDepartment of Nutrition Sciences, University of Alabama at Birmingham, 1675 University Boulevard, Birmingham, AL 35294, USA

^bThe Birmingham Veterans Affairs Medical Center, Birmingham, AL 35233, USA

^*Corresponding author. E-mail address: khaledm@uab.edu (M.A. Khaled).

Corresponding Author

Mohammad A. Khaled

Received 23 September 2008, Revised 10 December 2008, Accepted 19 January 2009, Available Online 25 February 2009.

DOI: 10.1016/j.artres.2009.01.004 How to use a DOI?
Keywords: H. pylori; Inflammation; Homocysteine; Obesity; African Americans
Abstract: African Americans are more susceptible to develop insulin resistance, obesity, Type 2 diabetes, and coronary heart disease (CHD), and systemic inflammation is central to the pathophysiology of these chronic diseases. African Americans are also more likely to contract H. pylori (cagA) infections during their childhood. However, the contribution of H. pylori infection to the degree of overall systemic inflammation in these chronic diseases is not known. Therefore, we studied 46 apparently healthy African Americans, over 40 years of age who were infected with H. pylori (cagA). These volunteers were assessed at baseline and after treatment with triple regimen drug therapy to eradicate H. pylori. All but 3 subjects were found to be free of this infection by urea breath test (UBT) after the treatment period. No hyperhomocysteinemia was found in these subjects and there were no significant changes in the level of homocysteine (tHcy), folate and B₁₂; however, CRP levels measured by high sensitivity assay showed a significant (p = 0.02) decrease 2 months after the eradication. We further stratified CRP values according to the BMI <27 and >27. There was more profound reduction in CRP in the more obese group (i.e., BMI >27) from 54.26 ± 23.67 to 18.73 ± 17.39 mg/l (p = 0.01), compared with the leaner subjects in whom CRP decreases from 8.88 ± 6.23 to 4.94 ± 6.21 mg/L (p = 0.04), after eradication of the H. pylori (cagA) infection. The level of CRP, however, remained significantly higher in the obese subjects even after the eradication of this infection, indicative of a smaller residual influence of adiposity on CRP. Thus, a major component of systemic inflammation in African Americans may be attributable to chronic H. pylori infection.
Open Access: This is an open access article distributed under the CC BY-NC license.

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<Previous Article In Issue

Journal: Artery Research
Volume-Issue: 3 - 1
Pages: 39 - 42
Publication Date: 2009/02/25
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2009.01.004 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - Nuzhat R. Siddiqui
AU  - W. Timothy Garvey
AU  - Mohammad A. Khaled
PY  - 2009
DA  - 2009/02/25
TI  - H. pylori-induced higher C-reactive protein in obese African Americans
JO  - Artery Research
SP  - 39
EP  - 42
VL  - 3
IS  - 1
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2009.01.004
DO  - 10.1016/j.artres.2009.01.004
ID  - Siddiqui2009
ER  -

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