Artery Research

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Volume 8, Issue 3, September 2014, Pages 73 - 79

24-h ambulatory pulse wave velocity and central blood pressure in type 2 diabetes

Authors
C. Krogagera, *, N.B. Rossena, b, E. Laugesenb, S.T. Knudsenb, P.L. Poulsenb, K.W. Hansena
aDiagnostic Center, Regional Hospital Silkeborg, Aarhus University Hospital, Denmark
bDepartment of Endocrinology and Internal Medicine, Aarhus University Hospital, Denmark
*Corresponding author. Flintebakken 81, DK-8240 Risskov, Denmark. Tel.: +45 31550777. E-mail address: chris.krogager@hotmail.com (C. Krogager).
Corresponding Author
C. Krogager
Received 25 February 2014, Revised 22 April 2014, Accepted 23 April 2014, Available Online 7 June 2014.
DOI
10.1016/j.artres.2014.04.004How to use a DOI?
Keywords
Ambulatory; Pulse wave velocity; Central blood pressure; Augmentation index; Brachial cuff; Pulse wave analysis; Arteriograph; Diabetes
Abstract

Background: Pulse wave analysis from a brachial cuff permits ambulatory measurements of pulse wave velocity (PWV) and central blood pressure parameters. The diurnal variation of PWV in type 2 diabetes is unknown.

Methods: We evaluated the Arteriograph24 which is a brachial cuff based equipment for estimating PWV and central blood pressure data without the use of a transfer function, in 22 type 2 diabetic patients, who had two 24 h measurements performed.

Results: The mean number of valid day time and nighttime measurements were 29 (range 16–50) and 18 (11–25), respectively. 21 patients had at least one qualifying report. Nighttime PWV was significantly lower than during the day (9.1 vs. 9.7 ± 0.8 mm/s, p < 0.01). Systolic aortic blood pressure was 6 mmHg lower than brachial blood pressure in the day time (p < 0.01) and 4 mmHg lower during the night (p < 0.05). Each single measurement was standardized with the 24 h average as reference thus generating data from 1004 paired observations. The standardized PWV correlated with standardized values of heart rate (r = 0.24, p < 0.001) and systolic aorta blood pressure (r = 0.20, p < 0.001). A stepwise multiple regression model with standardized pulse wave velocity as dependent variable included standardized heart rate, systolic aorta blood pressure and a dummy variable for day/night status (R2 = 0.091, p < 0.001).

Conclusion:The Arteriograph24 is applicable for research purpose. PVW in type 2 diabetes is modestly reduced during the night. The intraindividual variation of heart rate contributed independently to the variation of PWV.

Copyright
© 2014 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

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Next Article In Issue>
Journal
Artery Research
Volume-Issue
8 - 3
Pages
73 - 79
Publication Date
2014/06/07
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2014.04.004How to use a DOI?
Copyright
© 2014 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - C. Krogager
AU  - N.B. Rossen
AU  - E. Laugesen
AU  - S.T. Knudsen
AU  - P.L. Poulsen
AU  - K.W. Hansen
PY  - 2014
DA  - 2014/06/07
TI  - 24-h ambulatory pulse wave velocity and central blood pressure in type 2 diabetes
JO  - Artery Research
SP  - 73
EP  - 79
VL  - 8
IS  - 3
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2014.04.004
DO  - 10.1016/j.artres.2014.04.004
ID  - Krogager2014
ER  -