Artery Research

Volume 12, Issue C, December 2015, Pages 54 - 59

Regional differences in the vascular response to CO2 among cerebral, ocular, and mesenteric vessels

Authors
A. Miyajia, T. Ikemurab, Y. Hamadaa, N. Hayashia, *
aGraduate School of Decision Science and Technology, Tokyo Institute of Technology, Meguro, Tokyo 152-8852, Japan
bFaculty of Sport Science, Waseda University, Tokorozawa, Saitama, 359-1192, Japan
*Corresponding author. Tel./fax: +81 3 57343434. E-mail address: naohayashi@hum.titech.ac.jp (N. Hayashi).
Corresponding Author
N. Hayashi
Received 15 July 2015, Accepted 25 August 2015, Available Online 6 September 2015.
DOI
10.1016/j.artres.2015.08.001How to use a DOI?
Keywords
Cerebral circulation; Ocular circulation; CO2 reactivity; Endothelial function
Abstract

Background: It is well-known that cerebral and ocular vessels are highly sensitive to changes in the partial pressure of CO2 (PETCO2). However, it is unclear whether there are regional differences in the magnitude of the vascular response to CO2 (CO2 reactivity) in various vessels of a single individual, and whether there is a relationship in the CO2 reactivity of specific vessels between different individuals.

Methods: We compared the CO2 reactivity of the superior mesenteric artery (SMA), middle cerebral artery (MCA), retinal artery (RA), and retinal and choroidal vessels (RCV) during a 3-min inhalation of CO2-rich air (5%) in 70 subjects.

Results: The blood flow velocities in the MCA, RA, and RCV significantly increased by 21 ± 2% (mean ± SE), 9 ± 1%, and 7 ± 2%, respectively (P < 0.05) during hypercapnia, whereas that in the SMA did not change significantly (−17 ± 11%). The CO2 reactivity–the relative change in blood flow to a given change in PETCO2–was significantly greater in the MCA (2.2 ± 0.2%/mmHg) than in the RA and RCV (0.9 ± 0.1%/mmHg and 0.8 ± 0.2%/mmHg, respectively). There was a weak correlation in the CO2 reactivity only between RA and RCV (r = 0.43, P < 0.05).

Conclusion: These findings indicate that the CO2 reactivity can vary even in cerebral and ocular vessels, although the correlation is weak.

Copyright
© 2015 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
12 - C
Pages
54 - 59
Publication Date
2015/09/06
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2015.08.001How to use a DOI?
Copyright
© 2015 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - A. Miyaji
AU  - T. Ikemura
AU  - Y. Hamada
AU  - N. Hayashi
PY  - 2015
DA  - 2015/09/06
TI  - Regional differences in the vascular response to CO2 among cerebral, ocular, and mesenteric vessels
JO  - Artery Research
SP  - 54
EP  - 59
VL  - 12
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2015.08.001
DO  - 10.1016/j.artres.2015.08.001
ID  - Miyaji2015
ER  -