Artery Research

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Volume 16, Issue C, December 2016, Pages 25 - 33

Recent developments in near-infrared spectroscopy (NIRS) for the assessment of local skeletal muscle microvascular function and capacity to utilise oxygen

Authors
Siana Jones*, Scott T. Chiesa, Nishi Chaturvedi, Alun D. Hughes
Institute of Cardiovascular Science, University College London, WC1E 6BT, UK
*Corresponding author. UCL Institute of Cardiovascular Science, 10th Floor, 1-19 Torrington Place, London WC1E 7HB, UK. Fax: +44 207 594 1706. E-mail address: siana.jones@ucl.ac.uk (S. Jones).
Corresponding Author
Siana Jones
Received 28 July 2015, Revised 4 February 2016, Accepted 8 September 2016, Available Online 28 September 2016.
DOI
10.1016/j.artres.2016.09.001How to use a DOI?
Keywords
Near-infrared spectroscopy; Skeletal muscle; Exercise
Abstract

Purpose of review: Continuous wave near infrared spectroscopy (CW NIRS) provides non-invasive technology to measure relative changes in oxy- and deoxy-haemoglobin in a dynamic environment. This allows determination of local skeletal muscle O2 saturation, muscle oxygen consumption ( V˙O2 ) and blood flow. This article provides a brief overview of the use of CW NIRS to measure exercise-limiting factors in skeletal muscle.

Recent findings: NIRS parameters that measure O2 delivery and capacity to utilise O2 in the muscle have been developed based on response to physiological interventions and exercise. NIRS has good reproducibility and agreement with gold standard techniques and can be used in clinical populations where muscle oxidative capacity or oxygen delivery (or both) are impaired. CW NIRS has limitations including: the unknown contribution of myoglobin to the overall signals, the impact of adipose tissue thickness, skin perfusion during exercise, and variations in skin pigmentation. These, in the main, can be circumvented through appropriate study design or measurement of absolute tissue saturation.

Summary: CW NIRS can assess skeletal muscle O2 delivery and utilisation without the use of expensive or invasive procedures and is useable in large population-based samples, including older adults.

Copyright
© 2016 The Authors. Published by Elsevier B.V. on behalf of Association for Research into Arterial Structure and Physiology.
Open Access
This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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<Previous Article In Issue
Next Article In Issue>
Journal
Artery Research
Volume-Issue
16 - C
Pages
25 - 33
Publication Date
2016/09/28
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2016.09.001How to use a DOI?
Copyright
© 2016 The Authors. Published by Elsevier B.V. on behalf of Association for Research into Arterial Structure and Physiology.
Open Access
This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

Cite this article

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TY  - JOUR
AU  - Siana Jones
AU  - Scott T. Chiesa
AU  - Nishi Chaturvedi
AU  - Alun D. Hughes
PY  - 2016
DA  - 2016/09/28
TI  - Recent developments in near-infrared spectroscopy (NIRS) for the assessment of local skeletal muscle microvascular function and capacity to utilise oxygen
JO  - Artery Research
SP  - 25
EP  - 33
VL  - 16
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2016.09.001
DO  - 10.1016/j.artres.2016.09.001
ID  - Jones2016
ER  -