Combinatorial effect of lower extremity blood flow restriction and low intensity endurance exercise on aorta of old male rats: Histomorphological and molecular approach

Mohammad-Abbas Bejeshk; Siyavash Joukar; Beydolah Shahouzehi; Majid Asadi-shekari; Mohammadamin Rajizadeh; Alireza Raji-amirhasani; Vida Naderi-boldaji

doi:10.1016/j.artres.2018.10.226

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Volume 24, Issue C, December 2018, Pages 22 - 31

Combinatorial effect of lower extremity blood flow restriction and low intensity endurance exercise on aorta of old male rats: Histomorphological and molecular approach

Authors

Mohammad-Abbas Bejeshk^a, Siyavash Joukar^b^{, c}^{, *}, Beydolah Shahouzehi^b, Majid Asadi-shekari^c, Mohammadamin Rajizadeh^c, Alireza Raji-amirhasani^a^{, c}, Vida Naderi-boldaji^a^{, c}

^aPhysiology Research Center, Institute of Basic and Clinical Physiology Sciences and Department of Physiology and Pharmacology, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran

^bCardiovascular Research Center, Institute of Basic and Clinical Physiology Sciences and Department of Physiology and Pharmacology, Afzalipour Faculty of Medicine, Kerman University of Medical Science, Kerman, Iran

^cNeuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran

^*Corresponding author. Cardiovascular Research Center, Institute of Basic and Clinical Physiology Sciences, Department of Physiology and Pharmacology, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, P. O. Box 7616914115, Kerman, Iran. Fax: +98 3433257671. E-mail addresses: sjokar@gmail.com, jokar@kmu.ac.ir (S. Joukar).

Corresponding Author

Siyavash Joukar

Received 10 August 2018, Revised 11 October 2018, Accepted 16 October 2018, Available Online 1 November 2018.

DOI: 10.1016/j.artres.2018.10.226 How to use a DOI?
Keywords: Blood flow restriction; Exercise training; Apelin receptor; Angiotensin receptor; Aorta wall thickness
Abstract: Objective: Given the importance of knowing the effects of blood flow restriction (BFR) plus exercise training (BFR training) on the cardiovascular system, present study conducted to determine the effect of combination of BFR with low intensity endurance exercise on aorta of old rats.

Methods: Animal groups were control (CTL), sham (Sh), BFR, exercise (Ex), sham + exercise (Sh + Ex), and BFR + exercise (BFR + Ex). BFR induced by partial closing of the bilateral femoral arteries and duration of exercise was 10 weeks.

Results: BFR induced increasing of aorta wall thickness and decreasing its elastin/collagen ratio. Training alone increased the expression of apelin (P < 0.05) and angiotensin AT2 receptor (AT2R) (P < 0.01 versus CTL, Sh and P < 0.05 versus BFR groups) and the elastin/collagen ratio (P < 0.001) but, decreased the expression of angiotensin AT1 receptor (AT1R) (P < 0.01 versus CTL, Sh and BFR groups), the AT1R/AT2R ratio and the wall thickness (P < 0.001) of aorta. In Ex + BFR group, the expression of mentioned receptors increased and reached to more than levels of Ex groups, and the AT1R/AT2R ratio reduced in comparison with CTL, Sh and BFR and was higher than training groups (P < 0.5). Exercise also reversed the negative effect of BFR on elastin/collagen ratio and wall thickness.

Conclusion: The beneficial effects of low intensity endurance exercise on aorta of aged male rats are conserved partially in presence of BFR.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 24 - C
Pages: 22 - 31
Publication Date: 2018/11/01
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2018.10.226 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - Mohammad-Abbas Bejeshk
AU  - Siyavash Joukar
AU  - Beydolah Shahouzehi
AU  - Majid Asadi-shekari
AU  - Mohammadamin Rajizadeh
AU  - Alireza Raji-amirhasani
AU  - Vida Naderi-boldaji
PY  - 2018
DA  - 2018/11/01
TI  - Combinatorial effect of lower extremity blood flow restriction and low intensity endurance exercise on aorta of old male rats: Histomorphological and molecular approach
JO  - Artery Research
SP  - 22
EP  - 31
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.226
DO  - 10.1016/j.artres.2018.10.226
ID  - Bejeshk2018
ER  -

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