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Volume 5, Issue 4, December 2015, Pages 405 - 407
Association of lipoprotein lipase gene with coronary heart disease in Sudanese population
Authors
Muzamil M. Abdel Hamidb, Safa Ahmedb, Awatif Salahe, Etayeb M.A. Tyrabb, Lemya M. Yahiac, Elbagire A. Elbashird, Hassan H. Musaa, *, hassanhm@uofk.edu
aFaculty of Medical Laboratory Sciences, University of Khartoum, Sudan
bInstitute of Endemic Diseases, University of Khartoum, Sudan
cFaculty of Medical Laboratory Sciences, National Ribat University, Sudan
dSudan Heart Center, Khartoum, Sudan
eFaculty of Medicine and Health Sciences, Al Neelain University, Sudan
*Corresponding author.
Corresponding Author
Hassan H. Musahassanhm@uofk.edu
Received 30 September 2014, Revised 14 April 2015, Accepted 19 April 2015, Available Online 27 May 2015.
- DOI
- 10.1016/j.jegh.2015.04.007How to use a DOI?
- Keywords
- Risk factors; Lipid profile; LPL gene; Coronary heart disease; Sudan
- Abstract
Cardiovascular disease is stabilizing in high-income countries and has continued to rise in low-to-middle-income countries. Association of lipid profile with lipoprotein lipase gene was studied in case and control subject. The family history, hypertension, diabetes mellitus, smoking and alcohol consumption were the most risk factors for early-onset of coronary heart disease (CHD). Sudanese patients had significantly (P < 0.05) lower TC and LDL-C levels compared to controls. Allele frequency of LPL D9N, N291S and S447X carrier genotype was 4.2%, 30.7% and 7.1%, respectively. We conclude that lipoprotein lipase polymorphism was not associated with the incidence of CHD in Sudan.
- Copyright
- © 2015 Ministry of Health, Saudi Arabia. Published by Elsevier Ltd.
- Open Access
- This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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Cite this article
TY - JOUR AU - Muzamil M. Abdel Hamid AU - Safa Ahmed AU - Awatif Salah AU - Etayeb M.A. Tyrab AU - Lemya M. Yahia AU - Elbagire A. Elbashir AU - Hassan H. Musa PY - 2015 DA - 2015/05/27 TI - Association of lipoprotein lipase gene with coronary heart disease in Sudanese population JO - Journal of Epidemiology and Global Health SP - 405 EP - 407 VL - 5 IS - 4 SN - 2210-6014 UR - https://doi.org/10.1016/j.jegh.2015.04.007 DO - 10.1016/j.jegh.2015.04.007 ID - AbdelHamid2015 ER -