The “Urticostim” Phytocomposition’s Impact on the Hematological and Immunological Status of Experimental Animals

DOI

10.2991/assehr.k.200113.130How to use a DOI?

Keywords

rat blood count, phytodrug, phytotherapy, phytocomposition, hematological, biochemical, immunological indicators

Abstract

An important area of veterinary biotechnology is creation of medications made of plant tissues for prevention and treatment of various animal diseases. The objective was to study the new phytocomposition “Urticostim” effect on hematological and immunological blood parameters of rats. The experimental work was carried out in accordance with the Guidelines for preclinical drug research (2012). The animals were subcutaneously injected with Uriticostim phytopreparation in doses of 0.1 ml/kg, 1.0 ml/kg and 2.0 ml/kg of body weight once a day for 14 days. During the experimental period of observation, death and behavior abnormalities of animals were not noted. All the doses do not cause significant changes in the number of white blood cells and platelets and hemoglobin concentration. Doses of 0.1 ml/kg and 2.0 ml/kg of body weight contributed to a significant increase in the number of red blood cells compared with the control indices by 8An important area of veterinary biotechnology is creation of medications made of plant tissues for prevention and treatment of various animal diseases. The objective was to study the new phytocomposition “Urticostim” effect on hematological and immunological blood parameters of rats. The experimental work was carried out in accordance with the Guidelines for preclinical drug research (2012). The animals were subcutaneously injected with Uriticostim phytopreparation in doses of 0.1 ml/kg, 1.0 ml/kg and 2.0 ml/kg of body weight once a day for 14 days. During the experimental period of observation, death and behavior abnormalities of animals were not noted. All the doses do not cause significant changes in the number of white blood cells and platelets and hemoglobin concentration. Doses of 0.1 ml/kg and 2.0 ml/kg of body weight contributed to a significant increase in the number of red blood cells compared with the control indices by 8% and 3An important area of veterinary biotechnology is creation of medications made of plant tissues for prevention and treatment of various animal diseases. The objective was to study the new phytocomposition “Urticostim” effect on hematological and immunological blood parameters of rats. The experimental work was carried out in accordance with the Guidelines for preclinical drug research (2012). The animals were subcutaneously injected with Uriticostim phytopreparation in doses of 0.1 ml/kg, 1.0 ml/kg and 2.0 ml/kg of body weight once a day for 14 days. During the experimental period of observation, death and behavior abnormalities of animals were not noted. All the doses do not cause significant changes in the number of white blood cells and platelets and hemoglobin concentration. Doses of 0.1 ml/kg and 2.0 ml/kg of body weight contributed to a significant increase in the number of red blood cells compared with the control indices by 8% and 3%, respectively. A dose of 0.1 ml/kg caused a decrease in the bilirubin concentration of rats by 30An important area of veterinary biotechnology is creation of medications made of plant tissues for prevention and treatment of various animal diseases. The objective was to study the new phytocomposition “Urticostim” effect on hematological and immunological blood parameters of rats. The experimental work was carried out in accordance with the Guidelines for preclinical drug research (2012). The animals were subcutaneously injected with Uriticostim phytopreparation in doses of 0.1 ml/kg, 1.0 ml/kg and 2.0 ml/kg of body weight once a day for 14 days. During the experimental period of observation, death and behavior abnormalities of animals were not noted. All the doses do not cause significant changes in the number of white blood cells and platelets and hemoglobin concentration. Doses of 0.1 ml/kg and 2.0 ml/kg of body weight contributed to a significant increase in the number of red blood cells compared with the control indices by 8% and 3%, respectively. A dose of 0.1 ml/kg caused a decrease in the bilirubin concentration of rats by 30% compared with the control indices. Daily administration of a 2.0 ml/kg dose for 14 days led to an increase in urea concentration by 20An important area of veterinary biotechnology is creation of medications made of plant tissues for prevention and treatment of various animal diseases. The objective was to study the new phytocomposition “Urticostim” effect on hematological and immunological blood parameters of rats. The experimental work was carried out in accordance with the Guidelines for preclinical drug research (2012). The animals were subcutaneously injected with Uriticostim phytopreparation in doses of 0.1 ml/kg, 1.0 ml/kg and 2.0 ml/kg of body weight once a day for 14 days. During the experimental period of observation, death and behavior abnormalities of animals were not noted. All the doses do not cause significant changes in the number of white blood cells and platelets and hemoglobin concentration. Doses of 0.1 ml/kg and 2.0 ml/kg of body weight contributed to a significant increase in the number of red blood cells compared with the control indices by 8% and 3%, respectively. A dose of 0.1 ml/kg caused a decrease in the bilirubin concentration of rats by 30% compared with the control indices. Daily administration of a 2.0 ml/kg dose for 14 days led to an increase in urea concentration by 20%. A dose of 0.1 ml/kg increased the absolute number of lymphocytes due to all populations of lymphoid cells. Quantitative fluctuations of T and B lymphocytes and cytotoxic T lymphocytes were characterized by an increase of 1.58, 1.66 and 1.47 times, respectively, relative to the control group indices. With an increase in the Urticostim dose by 10-20 times, a significant decrease in the concentration of T lymphocytes to 0.5±0.2 thousand/μl was noted versus 1.2±0.1 thousand/μl in the control index, as well as cytotoxic T lymphocytes – up to 1.2±0.2 thousand/μl versus 1.9±0.2 thousand/μl. The number of B lymphocytes was at the same level as the control values.

Copyright

© 2020, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Valentina Veretennikova
AU  - Tatyana Boyko
AU  - Vasily Vlasenko
AU  - Vitaliy Shitikov
PY  - 2020
DA  - 2020/01/29
TI  - The “Urticostim” Phytocomposition’s Impact on the Hematological and Immunological Status of Experimental Animals
BT  - Proceedings of the International Scientific Conference The Fifth Technological Order: Prospects for the Development and Modernization of the Russian Agro-Industrial Sector (TFTS 2019)
PB  - Atlantis Press
SP  - 17
EP  - 20
SN  - 2352-5398
UR  - https://doi.org/10.2991/assehr.k.200113.130
DO  - 10.2991/assehr.k.200113.130
ID  - Veretennikova2020
ER  -