Process Monitoring and Control of Drug Fluidized Bed Granulation and Its New Application

DOI

10.2991/assehr.k.220701.027How to use a DOI?

Keywords

Fluidized bed granulation; Process analytical technology; Process automation; Process understanding

Abstract

Nowadays, fluidized bed granulation is a widely used technique in the pharmaceutical industry. Several factors, including process settings, powder qualities, and binder properties, impact its performance. The monitoring of the fluidized bed granulation process is a complex process. This paper describes the fluidized bed granulation process’s real-time online feedback control method. The focus of this study is on a Process analysis technology(PAT) based feedback control system for batch processing monitoring of fluidized bed granulation operations. It promotes the advancement of fluidized bed granulation technology from laboratory to mass production, giving a more efficient and cost-effective monitoring method for the pharmaceutical industry, based on the PAT process. In addition, fluid bed-based granulation produces particles with lower density and more porous structure, thus improving the water solubility of drugs.

Copyright

© 2022 The Authors. Published by Atlantis Press SARL.

Open Access

This is an open access article distributed under the CC BY-NC 4.0 license.

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TY  - CONF
AU  - Yaoyao Wang
PY  - 2022
DA  - 2022/07/04
TI  - Process Monitoring and Control of Drug Fluidized Bed Granulation and Its New Application
BT  - Proceedings of the 2022 International Conference on Science and Technology Ethics and Human Future (STEHF 2022)
PB  - Atlantis Press
SP  - 132
EP  - 137
SN  - 2352-5398
UR  - https://doi.org/10.2991/assehr.k.220701.027
DO  - 10.2991/assehr.k.220701.027
ID  - Wang2022
ER  -