Multigenerational Effect of piRNA on Neuronal Structure Change of Mice Induced by Odor-fear Conditioning

DOI

10.2991/assehr.k.220401.047How to use a DOI?

Keywords

piRNA; transgenerational memory; epigenetics

Abstract

This paper focuses on the biological relationship between piRNA and transgenerational memory in mice, and in it describes an experiment that can determine the existence of such relationship or not. piRNA is a type of non-coding RNA that is recently found and has potential importance in the field of epigenetics, especially transgenerational memory. The presence of such memory is usually checked with odor-fear testing for generations of mice. In animal body, it is discovered that piRNA needs the accompaniment of PIWI protein to be produced or to carry out its normal function. Therefore, in the experiment, we use loxP and CRE protein to eliminate the PIWI protein, which is essential for piRNA production, from all cells. The mice with no piRNA interbreed, and this paper looks at the mice’s response in the second generation to odor-fear test as a dependent variable. If the response changes when piRNA is eliminated, that means piRNA is related to transgenerational memory, at least with the genes that are important to odor-fear testing. If such hypothesis is proved, future research can look at the detailed mechanism of how piRNA works to alter epigenetic information.

Copyright

© 2022 The Authors. Published by Atlantis Press SARL.

Open Access

This is an open access article distributed under the CC BY-NC 4.0 license.

Download article (PDF)

TY  - CONF
AU  - Yi Zong
PY  - 2022
DA  - 2022/04/08
TI  - Multigenerational Effect of piRNA on Neuronal Structure Change of Mice Induced by Odor-fear Conditioning
BT  - Proceedings of the 2022 International Conference on Social Sciences and Humanities and Arts (SSHA 2022)
PB  - Atlantis Press
SP  - 230
EP  - 236
SN  - 2352-5398
UR  - https://doi.org/10.2991/assehr.k.220401.047
DO  - 10.2991/assehr.k.220401.047
ID  - Zong2022
ER  -