Effects of Total Anthraquinones of Polygonum Cuspidatum on the Levels of Insulin, Leptin and C-Peptide in Serum in Diabete Rat Model

DOI

10.2991/ssemse-15.2015.326How to use a DOI?

Keywords

Total anthraquinone of Polygonum cuspidatum (TAPC); Diabete model; Streptozotocin; Insulin antibody; Leptin; C-peptide.

Abstract

To investigate the effect of total anthraquinone of Polygonum cuspidatum (TAPC) in diabete rats which were established by streptozotocin. Method: The diabete rat model was established by injected with streptozotocin, and then randomized into 5 groups. Which were fed with high dosage TAPC group, medium dosage TAPC group, low dosage TAPC group (400mg•kg-1,200mg•kg-1,100mg•kg-1), metformin group (208 mg•kg 1) and model group. Control group was set up with healthy normal rats. All the rats were administrated once a day for 30 days. Blood glucose (BG) in the limosis were measured on the 20, 30 day and then rats were sacrificed. The levels of insulin, insulin antibody, leptin, C-peptide in orbital blood were measured. Results: Diabetic model rats successfully. Compared with model group, The high dosage TAPC group can significantly reduce the level of blood suga on 30 day(P<0.01), Can significantly reduce the level of blood suga on 20 day (P<0.05); The medium dosage TAPC group significantly reduce the level of blood suga on 20, 30 day (P<0.01); The medium and low dosage TAPC group significantly increased the level of insulin (P<0.01); Each dosage TAPC group can significantly reduce the level of C-peptide (P<0.01). Conclusion: TAPC has good hypoglycemic effect on the diabete rats established by injection of streptozotocin

Copyright

© 2015, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Ming Bai
AU  - Yan Li
AU  - Mingsan Miao
AU  - Ting Wang
AU  - Yuyin Xu
PY  - 2015/11
DA  - 2015/11
TI  - Effects of Total Anthraquinones of Polygonum Cuspidatum on the Levels of Insulin, Leptin and C-Peptide in Serum in Diabete Rat Model
BT  - Proceedings of the 2015 International Conference on Social Science, Education Management and Sports Education
PB  - Atlantis Press
SP  - 1267
EP  - 1270
SN  - 2352-5398
UR  - https://doi.org/10.2991/ssemse-15.2015.326
DO  - 10.2991/ssemse-15.2015.326
ID  - Bai2015/11
ER  -