The Gene Expression Profile of AIDS Patients with Tuberculosis Based on Bioinformatics Analysis

DOI

10.2991/sohe-18.2018.23How to use a DOI?

Keywords

AIDS, Tuberculosis, Differentially Expressed Genes, Bioinformatics

Abstract

Objective To analyze the differentially expressed genes in peripheral blood of AIDS patients with TB and explore the biological regulatory mechanism and network of key proteins, providing new evidence for early diagnosis and clinical treatment of AIDS patients combined with tuberculosis. Methods Microarray gene chip data of AIDS patients with TB was downloaded from public databases GEO ans imported into the analysis software STRING, PANTHER, and GenClip. The gene expression profiles, protein interaction networks, the process of molecular biology, gene function were analyzed. Results The expression profiles of 15,529 genes between the two groups of patients were similar; gene expression profiles from 44 subjects were highly correlated; 251 differentially expressed genes had a good diagnostic capabilities in the diagnosis of HIV/TB infection; CDC5L (cell division cycle 5 like), EIF4E (eukaryotic translation initiation factor 4E), RBBP7 (RB binding protein 7, chromatin remodeling factor) might be the key genes in the diagnosis of HIV/TB infection; differentially expressed genes and positive regulators showed some functions, including cellular function , RNA binding and cellular metabolic process. Conclusions The incidence of HIV/TB infection might closely related to CDC5L, EIF4E and RBBP7, which mainly related to cellular function and RNA binding, cellular metabolic process and other biological functions could play a role in its development, which provide some reference in diagnosis of HIV/TB infection.

Copyright

© 2018, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Yong-hong Ma
AU  - Jiao Tan
AU  - Ming-juan Shi
AU  - Jing Lei
AU  - Rong-qiang Zhang
PY  - 2018/05
DA  - 2018/05
TI  - The Gene Expression Profile of AIDS Patients with Tuberculosis Based on Bioinformatics Analysis
BT  - Proceedings of the 2018 Symposium on Health and Education (SOHE 2018)
PB  - Atlantis Press
SP  - 130
EP  - 137
SN  - 2352-5398
UR  - https://doi.org/10.2991/sohe-18.2018.23
DO  - 10.2991/sohe-18.2018.23
ID  - Ma2018/05
ER  -