Development of Ketorolac Analysis in Water Samples using Micellar Electrokinetic Chromatography
Authors
Dadan Hermawan1, *, Cacu Cacu1, Amin Fatoni1, Suwandri1, Wan Aini Wan Ibrahim2, Hassan Y Aboul-Enein3
1Department of Chemistry, Faculty of Mathematics and Natural Science, Jenderal Soedirman University, Indonesia
2Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, 81310 Johor Bahru, Malaysia
3Department of Pharmaceutical and Medical Chemistry, Pharmaceutical and Drug Industries Research Division, National Research Centre (NRC), Dokki, Cairo, Egypt
*Corresponding author. Email: dadan.hermawan@unsoed.ac.id
Corresponding Author
Dadan Hermawan
Available Online 25 May 2022.
- DOI
- 10.2991/apr.k.220503.003How to use a DOI?
- Keywords
- Ketorolac; Micellar electrokinetic chromatography; Water sample
- Abstract
Quantitative determination of ketorolac, a nonsteroidal anti-inflammatory drug (NSAID) in water samples was reported using the micellar electrokinetic chromatography (MEKC) method. The on-line preconcentration technique at MEKC was then investigated to increase the detection sensitivity of ketorolac. A 6-fold increase in sensitivity factor was achieved using normal stacking mode (NSM)-MEKC. The average recovery of ketorolac in tap water samples was 102.16% (RSD = 0.06%). The current NSM-MEKC method is simple, has short analysis time, high accuracy, and uses fewer organic solvents (environmentally friendly).
- Copyright
- © 2022 The Authors. Published by Atlantis Press International B.V.
- Open Access
- This is an open access article distributed under the CC BY-NC 4.0 license.
Cite this article
TY - CONF AU - Dadan Hermawan AU - Cacu Cacu AU - Amin Fatoni AU - Suwandri AU - Wan Aini Wan Ibrahim AU - Hassan Y Aboul-Enein PY - 2022 DA - 2022/05/25 TI - Development of Ketorolac Analysis in Water Samples using Micellar Electrokinetic Chromatography BT - Proceedings of the Soedirman International Conference on Mathematics and Applied Sciences (SICOMAS 2021) PB - Atlantis Press SP - 12 EP - 16 SN - 2352-541X UR - https://doi.org/10.2991/apr.k.220503.003 DO - 10.2991/apr.k.220503.003 ID - Hermawan2022 ER -