Analysis of Gene Mutations and Prognosis in Acute Myeloid Leukemia
- DOI
- 10.2991/assehr.k.220105.175How to use a DOI?
- Keywords
- gene mutations; acute myeloid leukemia; prognosis; occurrence; pathology
- Abstract
Acute myeloid leukemia (AML) is a malignant tumor that begins in the bone marrow and swiftly spreads throughout the body. Low erythrocyte counts, high leukocyte counts, and low thrombocyte counts are common symptoms of AML patients. Chromosomal abnormalities, cytogenetic deficiencies, and gene mutations are harbored by many people with AML. In recent years, the importance of cytogenetic deficiencies in prognosis and treatment has been proven by many studies. By understanding the gene mutations in AML, we can be provided with new insights of the pathogenesis of acute myeloid leukemia and we can better refine our treatment methods of AML. In this analysis, we can know that, without FLT3-ITD mutations, NPM1 mutations can improve the prognosis of CN AML patients, but NPM1with FLT-ITD mutation may result in bad prognosis. Also, FLT3 mutations are linked to a higher recurrence risk and a lower survival rate. RAS mutations were linked to a lower survival rate in AML patients undergoing induction chemotherapy. Patients with AML1/ETO showed a higher CR rate and survival rate.
- Copyright
- © 2022 The Authors. Published by Atlantis Press SARL.
- Open Access
- This is an open access article under the CC BY-NC license.
Cite this article
TY - CONF AU - Zihan Wang PY - 2022 DA - 2022/01/17 TI - Analysis of Gene Mutations and Prognosis in Acute Myeloid Leukemia BT - Proceedings of the 2021 International Conference on Social Development and Media Communication (SDMC 2021) PB - Atlantis Press SP - 952 EP - 956 SN - 2352-5398 UR - https://doi.org/10.2991/assehr.k.220105.175 DO - 10.2991/assehr.k.220105.175 ID - Wang2022 ER -