The Development and Current Situation of mRNA Vaccines

DOI

10.2991/assehr.k.220105.158How to use a DOI?

Keywords

mRNA vaccines; mRNA; SAM; LNP; COVID-19

Abstract

In the past three decades, the use of RNA-based technology to develop preventive and therapeutic vaccines has attracted widespread attention and in-depth research.The proteins in our body coordinate with each other to perform their respective functions. And mRNA is like a set of procedures. Cells only need to process and synthesize proteins according to this set of procedures. The emergence of mRNA therapy is equivalent to using cells in the body as a factory for protein expression and transferring the expression process in vitro to the body, thus greatly shortening the development time. Moreover, by customizing the mRNA sequence, we can get any protein we want, allowing patients to produce their own therapeutic proteins, and promoting drug customization. There are two main types of mRNA vaccines currently in use, one is non-replicating mRNA(NRM) vaccines, and the other is self-amplifying (SAM) vaccines. This article summarizes the literature on mRNA vaccines published in the past 30 years, sorts out the development history of mRNA vaccines and the advanced technology of new crown vaccines, and reveals that mRNA vaccines have great research and development potential for rapid manufacturing and combating infectious diseases and other diseases.

Copyright

© 2022 The Authors. Published by Atlantis Press SARL.

Open Access

This is an open access article under the CC BY-NC license.

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TY  - CONF
AU  - Zilu Qu
PY  - 2022
DA  - 2022/01/17
TI  - The Development and Current Situation of mRNA Vaccines
BT  - Proceedings of the 2021 International Conference on Social Development and Media Communication (SDMC 2021)
PB  - Atlantis Press
SP  - 854
EP  - 858
SN  - 2352-5398
UR  - https://doi.org/10.2991/assehr.k.220105.158
DO  - 10.2991/assehr.k.220105.158
ID  - Qu2022
ER  -