Proceedings of the 4th International Conference on Public Administration, Health and Humanity Development (PAHHD 2024)

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RVM Modulates a Variety of Painful Conditions and Therapeutic Approaches

Authors
Yuzi Zhu1, Xianghong Jing2, Man Li3, *
1First School of Clinical Medicine, Heilongjiang University Of Chinese Medicine, Harbin, China
2Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, 100700, China
3School of Basic Medicine, Tongji Medical College, Key Laboratory of Anesthesiology and Resuscitation of Ministry of Education, Huazhong University of Science and Technology, Wuhan, 430030, China
*Corresponding author. Email: liman73@mails.tjmu.edu.cn
Corresponding Author
Man Li
Available Online 21 October 2024.
DOI
10.2991/978-2-38476-295-8_25How to use a DOI?
Keywords
Rostral ventromedial medulla (RVM); Pain modulation; Chemogenetics; Neuropathic pain; Deep brain stimulation (DBS)
Abstract

The article explores the complex role of the rostral ventromedial medulla (RVM) in pain modulation mechanisms and its correlation with neural activity and pain behavior. As a crucial relay station in the descending pain modulation system, the RVM can both amplify and attenuate pain signals. The review discusses how RVM regulate various types of painful conditions. Specifically, it examines RVM involvement in regulating neuropathic pain induced by chemotherapy, migraine, temporomandibular joint syndrome (TMJ), stress-induced pain, sickle cell disease (SCD) pain and stomofacial pain. Additionally, we explores which treatments can activate RVM and related neural circuit to modulate pain perception, such as exercise analgesia, transcutaneous electrical nerve stimulation (TENS), electroacupuncture, transcranial direct current stimulation (tDCS), and deep brain stimulation (DBS). These therapeutic approaches harness the RVM’s ability to regulate pain perception and improve pain-related behaviors.

Copyright
© 2024 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Volume Title
Proceedings of the 4th International Conference on Public Administration, Health and Humanity Development (PAHHD 2024)
Series
Advances in Social Science, Education and Humanities Research
Publication Date
21 October 2024
ISBN
978-2-38476-295-8
ISSN
2352-5398
DOI
10.2991/978-2-38476-295-8_25How to use a DOI?
Copyright
© 2024 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

risenwbib
TY  - CONF
AU  - Yuzi Zhu
AU  - Xianghong Jing
AU  - Man Li
PY  - 2024
DA  - 2024/10/21
TI  - RVM Modulates a Variety of Painful Conditions and Therapeutic Approaches
BT  - Proceedings of the 4th International Conference on Public Administration, Health and Humanity Development (PAHHD 2024)
PB  - Atlantis Press
SP  - 202
EP  - 210
SN  - 2352-5398
UR  - https://doi.org/10.2991/978-2-38476-295-8_25
DO  - 10.2991/978-2-38476-295-8_25
ID  - Zhu2024
ER  -