Triclisia Subcordata Oliv Aqueous Leaf Extract can influence Reproductive Hormones and Haematological Profiles of Mifepristone Threatened Pregnancy in Wistar Rats

DOI

10.2991/978-94-6463-306-1_7How to use a DOI?

Keywords

Triclisia subcordata oliv; mifepristone; pregnancy; reproductive hormones; haematology; dew; uterus

Abstract

Effect of Triclisia subcordata oliv aqueous leaf extract on reproductive hormones and haematological profiles of mifepristone threatened pregnancy in Wistar rats was investigated. Sexually matured rats comprising of 80 male and 80 female rats (150-220g) were purchased and paired up for reproduction after one week acclimatization period in the ratio of 2:2. The rats were sexed, and the pregnant females were housed in different plastic cages of eight groups with ten rats each. Group 1 is the normative control, while Group 2 is the experimental group (mifepristone only). On day 5 of their pregnancies, Groups 2-8 took mifepristone orally. Groups 3-8 were administered orally extract dosages of 100, 200, and 300 mg/kgbw (nonexposed and dew-exposed) respectively daily for 17 days. All analyses were performed using standard procedures. In comparison to the experimental control rats, administration of the extract (nonexposed and dew-exposed) significantly decreased white blood cell, lymphocytes, eusinophil counts but increased oestrogen, progesterone, packed cell volume, haemoglobin, red blood cell, mean cell volume and mean cell haemoglobin levels of treated rats. The 300mg/kgbw extract doses provided better protection there by sustaining the pregnancy as seen in stage 2 especially in those administered with dew-exposed. Histopathological examination of uterus showed histological normal uterus in normal control rats and slight deformation and enlargement of the uterus in the experimental control rats which was restored to normalcy in the treated rats. The result of this study improved suppressed hormones and haemapoietic markers using Triclisia subcordata leaf extract against threatened pregnancy in Wistar rats.

Copyright

© 2023 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Download article (PDF)

TY  - CONF
AU  - F. N. Okpara
AU  - E. O. Nwaichi
AU  - D. C. Belonwu
PY  - 2023
DA  - 2023/12/18
TI  - Triclisia Subcordata Oliv Aqueous Leaf Extract can influence Reproductive Hormones and Haematological Profiles of Mifepristone Threatened Pregnancy in Wistar Rats
BT  - Proceedings of the 6th Biennial Conference of Organization for Women in Science for the Developing World Nigeria (OWSD 2023)
PB  - Atlantis Press
SP  - 99
EP  - 136
SN  - 2468-5747
UR  - https://doi.org/10.2991/978-94-6463-306-1_7
DO  - 10.2991/978-94-6463-306-1_7
ID  - Okpara2023
ER  -