Anti-Inflammatory and Mucolytic Activity Test of Ethanol Extract Fennel Leaf (Foeniculum vulgare Mill.)

DOI

10.2991/978-94-6463-322-1_18How to use a DOI?

Keywords

COPD; Inflammation; Mucolytic; Foeniculum vulgarae; Fennel

ABSTRACT

Chronic Obstructive Pulmonary Disease (COPD) is a progressive lung disease characterized by chronic bronchitis, airway thickening, and emphysema. There are several main mechanisms of COPD, namely chronic inflammatory processes in the airways, oxidative stress, and disturbances in the balance between proteolytic and antiproteolytic. Fennel is one of the plants that has been widely used in traditional medicine including as an anti-inflammatory, antioxidant, and cough reduction. This study was conducted to determine the potential of fennel leaf ethanol extract to be used in COPD therapy. The ethanol extract of fennel leaf was obtained by maceration which was carried out for 3 × 24 h. The method used to determine anti-inflammatory activity in vitro is membrane stabilization by induction of a hypotonic solution. The mucolytic testing was carried out in vitro using cow intestinal mucus. The ethanol extract of fennel leaf in various concentrations (25,75 μg/mL; 51,50 μg/mL; 103 μg/mL; 206 μg/mL; 412 μg/mL) showed membrane stabilization and mucolytic activity. The ethanol extract of fennel leaf at a concentration of 412 μg/mL gave 53,5357% inhibition and could reduce the viscosity most. The results of the statistical test showed the ethanolic extracts of leaf with a concentration of 25,75 μg/mL; 51,5 μg/mL; 103 μg/mL; 206 μg/mL; 412 μg/mL have % inhibition and decrease in viscosity significantly different (p < 0,05) compared to the control group. Based on the results, the ethanol extract of fennel leaf had hemolysis inhibition and mucolytic activity, but it is not equivalent (not effective) to the comparison group.

Copyright

© 2023 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Syifatul Lutviani
AU  - Ita Nur Anisa
AU  - Andreanus A. Soemardji
PY  - 2023
DA  - 2023/12/30
TI  - Anti-Inflammatory and Mucolytic Activity Test of Ethanol Extract Fennel Leaf (Foeniculum vulgare Mill.)
BT  - Proceedings of the Conference on Natural Resources And Life Sciences 2022 (NRLS-BIO 2022)
PB  - Atlantis Press
SP  - 133
EP  - 137
SN  - 2468-5747
UR  - https://doi.org/10.2991/978-94-6463-322-1_18
DO  - 10.2991/978-94-6463-322-1_18
ID  - Lutviani2023
ER  -