Proceedings of the 1st Nusa Tenggara International Conference on Chemistry (NITRIC 2022)

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Synthesis and Antioxidant Activity of Calix[4]resorcinarene Derivatives Compounds

Authors
Emmy Yuanita1, *, Maria Ulfa1, Rizky Annisa Ramadhini1, Ni Komang Tri Dharmayani1, Aris Riyaldi1, Sudirman1
1Department of Chemistry, Faculty of Mathematics and Natural Sciences, University of Mataram, Mataram, Indonesia
*Corresponding author. Email: emmy_yuanita@unram.ac.id
Corresponding Author
Emmy Yuanita
Available Online 14 April 2023.
DOI
10.2991/978-94-6463-130-2_9How to use a DOI?
Keywords
Antioxidant activity; C-butilcalix[4]resorcinarene; C-phenylcalix[4]resorcinarene; Synthesis
Abstract

Synthesis of calix[4]resorcinarene derivatives and their activity as an antioxidant has been carried out. The calix[4]resorcinarene was synthesized through a condensation reaction of resorcinol, valeraldehyde, and benzaldehyde using HCl as a catalyst with ethanol as a solvent (73 ℃, 24 h). Two synthesized products, C-butilcalix[4]resorcinarene and C-phenylcalix[4]resorcinarene were successfully prepared with 44.70% and 43.5% yield, respectively. Their chemical structure was elucidated by Fourier Transform Infrared (FTIR) and Proton Nuclear Magnetic Resonance (1H-NMR) analysis. The antioxidant activity assay of these compounds was evaluated through an in vitro assay of 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals. The DPPH assay showed that the half-maximal inhibitory concentration (IC50) values of C-butylcalix[4]resorcinarene and C-phenylcalix[4]resorcinarene were 6.28 ppm and 18.76 ppm, respectively. This finding demonstrates that both C-butylcalix[4]resorcinarene and C-phenylcalix[4]resorcinarene have very strong antioxidant properties.

Copyright
© 2023 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Volume Title
Proceedings of the 1st Nusa Tenggara International Conference on Chemistry (NITRIC 2022)
Series
Atlantis Highlights in Chemistry and Pharmaceutical Sciences
Publication Date
14 April 2023
ISBN
978-94-6463-130-2
ISSN
2590-3195
DOI
10.2991/978-94-6463-130-2_9How to use a DOI?
Copyright
© 2023 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

risenwbib
TY  - CONF
AU  - Emmy Yuanita
AU  - Maria Ulfa
AU  - Rizky Annisa Ramadhini
AU  - Ni Komang Tri Dharmayani
AU  - Aris Riyaldi
AU  - Sudirman
PY  - 2023
DA  - 2023/04/14
TI  - Synthesis and Antioxidant Activity of Calix[4]resorcinarene Derivatives Compounds
BT  - Proceedings of the 1st Nusa Tenggara International Conference on Chemistry (NITRIC 2022)
PB  - Atlantis Press
SP  - 75
EP  - 82
SN  - 2590-3195
UR  - https://doi.org/10.2991/978-94-6463-130-2_9
DO  - 10.2991/978-94-6463-130-2_9
ID  - Yuanita2023
ER  -