Proceedings of the 2016 4th International Conference on Management Science, Education Technology, Arts, Social Science and Economics (msetasse-16)

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Research on the Intervention Effect of Polydatin of Hyperlipidemia Rats' Early Atherosclerosis

Authors
Enhong Ouyang, Junhua Liu, Hailiang Wei, Gengxi Li
Corresponding Author
Enhong Ouyang
Available Online November 2016.
DOI
10.2991/msetasse-16.2016.167How to use a DOI?
Keywords
Polydatin, Atherosclerosis, Hyperlipidemia.
Abstract

Purpose: to discuss the function of polydatin on regulating blood-lipid and anti-atherosclerosis. Method: feed rats with high-fat diet to establish early atherosclerosis model, after the model is established successfully, feed with high, medium and low dose of polydatin (160 80 40mg•kg-1•d-1), 8 weeks later, measure the rats' serum cholesterol (TC), triglyceride (TG), HDL-Cholesterol (HDL-C), LDL-Cholesterol (LDL-C), tumor necrosis factor (TNF- ), nitric oxide (NO) and inducible nitric oxide synthase (iNOS); take thoracic aorta to carry out oil red O dying to observe the deposition of aortic intimal lipid; take live to make regular HE dying to observe hepatic pathological changes. Result: high, medium and low dosage of polydatin can obviously reduce hyperlipidemia rats' serum TC TG LDL-C TNF- NO level and iNOS activity, improve HDL-C level, the difference is statistically significant (P <0.05). Meanwhile, polydatin can decrease the intraaortic leather fat deposition, improve the fatty degeneration and inflammatory cell infiltration of liver. Conclusion: polydatin has functions on regulating blood fat, decreasing the happen of atherosclerosis. This function may relate with its adjust NO and the formation of synthase.

Copyright
© 2016, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the 2016 4th International Conference on Management Science, Education Technology, Arts, Social Science and Economics (msetasse-16)
Series
Advances in Social Science, Education and Humanities Research
Publication Date
November 2016
ISBN
978-94-6252-263-3
ISSN
2352-5398
DOI
10.2991/msetasse-16.2016.167How to use a DOI?
Copyright
© 2016, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - CONF
AU  - Enhong Ouyang
AU  - Junhua Liu
AU  - Hailiang Wei
AU  - Gengxi Li
PY  - 2016/11
DA  - 2016/11
TI  - Research on the Intervention Effect of Polydatin of Hyperlipidemia Rats' Early Atherosclerosis
BT  - Proceedings of the 2016 4th International Conference on Management Science, Education Technology, Arts, Social Science and Economics (msetasse-16)
PB  - Atlantis Press
SP  - 780
EP  - 784
SN  - 2352-5398
UR  - https://doi.org/10.2991/msetasse-16.2016.167
DO  - 10.2991/msetasse-16.2016.167
ID  - Ouyang2016/11
ER  -