The Impact of Ultrasound on APP/PS1 Model Mouse

DOI

10.2991/mseee-17.2017.36How to use a DOI?

Keywords

Alzheimer´s disease, Amyloid plaques, Ultrasound.

Abstract

In this study, three-month-old APP / PS1 double transgenic mice were subjected to ultrasound intervention for investigating the effect of ultrasound intervention. The Morris water maze test showed that the ability of learning and memory of US group was significantly improved than that of the AD group (p <0.05), during the navigation and space exploration phases. The amyloid plaque content in the brain was detected by immunohistochemistry. The deposition of amyloid plaques in the brain of the US group was less than that in the AD group, but there was no significant difference between the CN group and the US group. The results showed that the learning and memory ability of APP / PS1 double transgenic mice was significantly improved after the intervention of ultrasound with frequency of 1MHz and power of 0.3W/cm2, and the amyloid plaques were reduced.

Copyright

© 2017, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Download article (PDF)

TY  - CONF
AU  - Li Li
AU  - Weiwei Wang
AU  - Wei Wu
AU  - Wanlin Zhang
AU  - Ying Gao
AU  - Chen Chen
PY  - 2017/08
DA  - 2017/08
TI  - The Impact of Ultrasound on APP/PS1 Model Mouse
BT  - Proceedings of the 2017 International Conference on Material Science, Energy and Environmental Engineering (MSEEE 2017)
PB  - Atlantis Press
SP  - 193
EP  - 199
SN  - 2352-5401
UR  - https://doi.org/10.2991/mseee-17.2017.36
DO  - 10.2991/mseee-17.2017.36
ID  - Li2017/08
ER  -