Evaluation of anti-hepatotoxic potential of Cassia javanica (L.) methanol extract against paracetamol-induced liver damage in Wistar albino rats

DOI

10.2991/msc-18.2018.40How to use a DOI?

Keywords

Cassia javanica, hepatoprotection, liver damage, paracetamol

Abstract

Species of Cassia (family Caesalpinaceae) are well known in India and other tropical countries for their medicinal values. This study evaluates the efficacy of the methanol extract of the leaves of Cassia javanica L. on paracetamol-induced liver damage in experimental rats. The animals were randomly divided into six groups of five animals each. While group I served as the normal control, group II-V serve as the test groups, and group VI as C. javanica control group. Hepatotoxicity was induced in the test groups via oral administration of paracetamol (2 g/kg b.wt). While group III-V were treated for 14 days with 125 mg/kg, 250 mg/kg and 500 mg/kg b.wt of C. javanica methanol extract respectively, group II served as positive control and was left untreated. The degree of hepatoprotection was assessed by estimating the levels of aspartate transaminases (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total bilirubin and tissue protein. Administration of methanol extract of C. javanica elicited protective action in groups III-V when compared to group II as the cell progress towards normalization evidenced by the significant decline in the elevated levels of marker enzymes (AST, ALT, ALP) and total bilirubin and an increase in tissue protein. The findings indicate that C. javanica has a hepatoprotective action against paracetamol-induced hepatic damage in Wistar rats and indeed validate its traditional use in the treatment of liver damage.

Copyright

© 2018, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Esther Lalhmingliani
AU  - Zodinpuii
AU  - R.K. Lalremtluangi
AU  - Lalramdinthara Chenkual
AU  - Lalthansangi
PY  - 2018/12
DA  - 2018/12
TI  - Evaluation of anti-hepatotoxic potential of Cassia javanica (L.) methanol extract against paracetamol-induced liver damage in Wistar albino rats
BT  - Proceedings of the Mizoram Science Congress 2018 (MSC 2018) - Perspective and Trends in the Development of Science Education and Research
PB  - Atlantis Press
SP  - 229
EP  - 232
SN  - 2352-5401
UR  - https://doi.org/10.2991/msc-18.2018.40
DO  - 10.2991/msc-18.2018.40
ID  - Lalhmingliani2018/12
ER  -