Formulation and Evaluation of Sprue Gel Preparations of Betel Leaf Extract (Piperis betle L.)

DOI

10.2991/978-2-38476-022-0_118How to use a DOI?

Keywords

Betel leaf; Sprue gel; Gelling agent; Carbopol; Xanthan gum

Abstract

Sprue is a disease that is often found in daily activities due to infection with the fungus Candida albicans. The community uses betel leaves to treat sprue by chewing the betel leaf until it is crushed, leaving it in the mouth for a while, especially on the affected area. The chemical content of betel leaf extract is saponins, flavonoids, and essential oil s that can treat sprue. The betel leaf extract was formulated into a gel preparation with variations of carbopol 934 and xanthan gum as a gelling agent. The purpose of this study was to formulate a stable and eligible betel leaf extract gel. This research is an experimental study by making several gel formulas using variations of carbopol 934 and xanthan gum at a concentration ratio of 1%:1%, 1.25%:0.75%, 0.75%:1.25% and addition of 10% betel leaf extract. Then performed an evaluation of the preparation for 28 days of storage, including pH, viscosity, homogeneity, dispersibility, syneresis/swelling, color, odor, and irritation. The results showed that the pH, viscosity, syneresis/swelling, dispersibility, homogeneity, color, odor, and irritation met the requirements for all three formulas for 28 days of storage. Betel leaf extract (Piperis betle L.) can be formulated into a gel preparation that is stable and meets the requirements. The best formula is produced with variations of carbopol 934 and xanthan gum 1%:1%.

Copyright

© 2023 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Minda Warnis
AU  - Ilham Marsandes
AU  - Atun Rohayati
AU  - Besse Mawaddah
AU  - Dewi Marlina
PY  - 2023
DA  - 2023/05/13
TI  - Formulation and Evaluation of Sprue Gel Preparations of Betel Leaf Extract (Piperis betle L.)
BT  - Proceedings of the 1st UMSurabaya Multidisciplinary International Conference 2021 (MICon 2021)
PB  - Atlantis Press
SP  - 1059
EP  - 1066
SN  - 2352-5398
UR  - https://doi.org/10.2991/978-2-38476-022-0_118
DO  - 10.2991/978-2-38476-022-0_118
ID  - Warnis2023
ER  -