Research on Non-linear Relationship among Histone Modifications in Yeast Genome
- DOI
- 10.2991/mebe-15.2015.102How to use a DOI?
- Keywords
- Histone modification; Pearson Correlation; MINE.
- Abstract
In the process of we studied chromosome modifications, we found the previous studies only focused on linear relationship between chemical modifications. So we interfered the data sets of the Yeast histone Methylation modification and Acetylation which are measured by Pothook et al. We got 16 kinds of protein modification date sets in the whole genome. Then we processed the each of data sets by aligning, averaging and normalizing data around the TSS (about 1000bp from upstream or downstream).After we grouped the whole genome histone modification data sets according to the Yeast genome transcription level data : one modified groups promote transcription, and the other modified groups inhibit transcription or are independent of transcription. In order to reveal the complex relationships between different transcriptional activity of genetically modified, we calculated the correlation among several modifications with two by algorithms–Pearson correlation analysis and MINE proposed by David N. Reshelf et al. We analyzed the results and got some non-linear relationship between histone modifications. We also found that the association between histone modifications stronger in the same modified group.
- Copyright
- © 2015, the Authors. Published by Atlantis Press.
- Open Access
- This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - CONF AU - Panfeng Chen AU - JiHua Feng AU - Zenhui Shan AU - Henhen Wei AU - Huan Hu PY - 2015/04 DA - 2015/04 TI - Research on Non-linear Relationship among Histone Modifications in Yeast Genome BT - Proceedings of the 2015 International Conference on Materials, Environmental and Biological Engineering PB - Atlantis Press SP - 433 EP - 437 SN - 2352-5401 UR - https://doi.org/10.2991/mebe-15.2015.102 DO - 10.2991/mebe-15.2015.102 ID - Chen2015/04 ER -