Molecular Modeling Studies on Binding of Chlorotetracycline and Enoxacin to Human Serum Albumin

DOI

10.2991/mebe-15.2015.84How to use a DOI?

Keywords

Molecular Modeling; Chlorotetracycline; Enoxacin; Human Serum Albumin

Abstract

The interactions of chlorotetracycline (CTC) and enoxacin (ENX) with human serum albumin (HSA) had been studied by molecular modeling method. Molecular docking revealed that both CTC and ENX bound to site I (subdomain IIA) of HSA through multiple interactions, such as hydrogen bonds, hydrophobic effect and polar force. Moreover, the systems’ (CTC-HSA and ENX-HSA) Gibbs free energies ( G) were -27.50kJ mol-1 and -29.93kJ mol-1, respectively.

Copyright

© 2015, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Taoying Hu
AU  - Ying Liu
PY  - 2015/04
DA  - 2015/04
TI  - Molecular Modeling Studies on Binding of Chlorotetracycline and Enoxacin to Human Serum Albumin
BT  - Proceedings of the 2015 International Conference on Materials, Environmental and Biological Engineering
PB  - Atlantis Press
SP  - 355
EP  - 358
SN  - 2352-5401
UR  - https://doi.org/10.2991/mebe-15.2015.84
DO  - 10.2991/mebe-15.2015.84
ID  - Hu2015/04
ER  -